DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Hwangseo | ko |
dc.contributor.author | Jeong, Yujeong | ko |
dc.contributor.author | Hong, Sungwoo | ko |
dc.date.accessioned | 2013-03-09T21:12:24Z | - |
dc.date.available | 2013-03-09T21:12:24Z | - |
dc.date.created | 2012-04-06 | - |
dc.date.created | 2012-04-06 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.citation | BIOORGANIC MEDICINAL CHEMISTRY LETTERS, v.22, no.2, pp.1027 - 1030 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | http://hdl.handle.net/10203/97470 | - |
dc.description.abstract | VRAF murine sarcoma viral oncogene homologue B1 (BRAF) kinase has been considered to be a promising therapeutic target for various human cancers. We have been able to identify 24 novel BRAF kinase inhibitors with K-d values ranging from 0.4 to 10 mu M utilizing a structure-based de novo design method with the two known inhibitor scaffolds. Because these discovered inhibitors were also screened for having desirable physicochemical properties as a drug candidate, they deserve consideration for further investigation as anticancer agents. Structural features relevant to the stabilization of the newly identified inhibitors in the ATP-binding site of BRAF are discussed in detail. (C) 2011 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | B-RAF KINASE | - |
dc.subject | GENETIC ALGORITHM | - |
dc.subject | DISCOVERY | - |
dc.subject | CARCINOMA | - |
dc.subject | SOLVATION | - |
dc.subject | MUTATIONS | - |
dc.subject | DOCKING | - |
dc.subject | CANCER | - |
dc.subject | POTENT | - |
dc.title | Structure-based de novo design and biochemical evaluation of novel BRAF kinase inhibitors | - |
dc.type | Article | - |
dc.identifier.wosid | 000299653500052 | - |
dc.identifier.scopusid | 2-s2.0-84855708686 | - |
dc.type.rims | ART | - |
dc.citation.volume | 22 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 1027 | - |
dc.citation.endingpage | 1030 | - |
dc.citation.publicationname | BIOORGANIC MEDICINAL CHEMISTRY LETTERS | - |
dc.identifier.doi | 10.1016/j.bmcl.2011.11.124 | - |
dc.contributor.localauthor | Hong, Sungwoo | - |
dc.contributor.nonIdAuthor | Park, Hwangseo | - |
dc.contributor.nonIdAuthor | Jeong, Yujeong | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | BRAF kinase | - |
dc.subject.keywordAuthor | Inhibitor | - |
dc.subject.keywordAuthor | Docking | - |
dc.subject.keywordAuthor | Anticancer agents | - |
dc.subject.keywordAuthor | De novo design | - |
dc.subject.keywordPlus | B-RAF KINASE | - |
dc.subject.keywordPlus | GENETIC ALGORITHM | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | SOLVATION | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | DOCKING | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | POTENT | - |
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