From skeletal muscle to cancer: Insights learned elucidating the function of tropomyosin
The tropomyosins (Tms) are a family of actin filament binding proteins that possess a simple dimeric alpha-helical coiled-coil structure along their entire length. Our knowledge of Tm structure and function has greatly expanded since they were first discovered in skeletal muscle almost 65 years ago. In multicellular organisms they exhibit extensive cell type specific isoform diversity. In this essay we discuss the genetic mechanisms by which this diversity is generated and its significance to actin-based cellular functions. (C) 2011 Elsevier Inc. All rights reserved.
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Issue Date
- 2012-01
- Language
- English
- Article Type
- Article
- Keywords
MOLECULAR-WEIGHT TROPOMYOSINS; RAS-TRANSFORMED FIBROBLASTS; CHICKEN-EMBRYO FIBROBLASTS; SIGNAL-REGULATED KINASE; TUMOR-SUPPRESSOR; NONMUSCLE TROPOMYOSIN; ACTIN CYTOSKELETON; TGF-BETA; ISOFORM EXPRESSION; OXIDATIVE STRESS
- Citation
JOURNAL OF STRUCTURAL BIOLOGY, v.177, no.1, pp.63 - 69
- ISSN
- 1047-8477
- Appears in Collection
- BS-Journal Papers(저널논문)
- Files in This Item
- There are no files associated with this item.
This item is cited by other documents in WoS
| ⊙ Detail Information in WoSⓡ | Click to see |  |
| ⊙ Cited 26 items in WoS | Click to see citing articles in |  |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.