Label-free optical control of arterial contraction

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The diameters of blood vessels, especially in the brain, change dynamically over time to provide sufficient blood supply as needed. No existing technique allows noninvasive control of vascular diameter in vivo. We report that label-free irradiation with a femtosecond pulsed laser can trigger blood vessel contraction in vivo. In response to laser irradiation, cultured vascular smooth muscle cells showed a rapid increase in calcium concentration, followed by cell contraction. In a murine thinned skull window model, laser irradiation focused in the arterial vessel wall caused localized vascular contraction, followed by recovery. The nonlinear nature of the pulsed laser allowed highly specific targeting of subcortical vessels without affecting the surrounding region. We believe that femtosecond pulsed laser irradiation will become a useful experimental tool in the field of vascular biology. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3316404]
Publisher
SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS
Issue Date
2010-01
Language
English
Article Type
Article
Keywords

FEMTOSECOND LASER; BLOOD-VESSELS; MUSCLE-CELLS; NORMAL BRAIN; TRANSFECTION; STIMULATION; RELEASE; DISEASE; STROKE; FLOW

Citation

JOURNAL OF BIOMEDICAL OPTICS, v.15

ISSN
1083-3668
DOI
10.1117/1.3316404
URI
http://hdl.handle.net/10203/97140
Appears in Collection
BiS-Journal Papers(저널논문)
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