Effect of microstructure on blood cell clogging in blood separators based on capillary action

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In this study, the blood cell clogging phenomenon occurring in blood separators based on capillary action is carefully investigated and how to minimize the reduction in plasma separation speed caused by clogging is discussed. Four different blood separators are fabricated on optically transparent glass substrates to clearly observe the blood plasma separation and the blood cell clogging in the microfluidic devices. Each separation experiment is captured by a high-speed video camera. The captured images are analyzed using a theoretical model proposed in this study to quantify the effect of the microstructure on the degree of blood cell clogging. Finally, design guidelines for the microstructure of the micro blood separator are discussed based on the analysis.
Publisher
SPRINGER
Issue Date
2009-02
Language
English
Article Type
Article
Citation

MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS, v.15, no.2, pp.227 - 233

ISSN
0946-7076
DOI
10.1007/s00542-008-0663-7
URI
http://hdl.handle.net/10203/96673
Appears in Collection
ME-Journal Papers(저널논문)
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