Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution

Cited 158 time in webofscience Cited 0 time in scopus
  • Hit : 574
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorvan de Ven, Anne L.ko
dc.contributor.authorKim, Pilhanko
dc.contributor.authorHaley, O'Harako
dc.contributor.authorFakhoury, Jean R.ko
dc.contributor.authorAdriani, Giuliako
dc.contributor.authorSchmulen, Jeffreyko
dc.contributor.authorMoloney, Padraigko
dc.contributor.authorHussain, Fazleko
dc.contributor.authorFerrari, Mauroko
dc.contributor.authorLiu, Xuewuko
dc.contributor.authorDecuzzi, Paoloko
dc.contributor.authorYun, Seok Hyunko
dc.date.accessioned2013-03-09T10:50:31Z-
dc.date.available2013-03-09T10:50:31Z-
dc.date.created2012-04-02-
dc.date.created2012-04-02-
dc.date.issued2012-02-
dc.identifier.citationJOURNAL OF CONTROLLED RELEASE, v.158, no.1, pp.148 - 155-
dc.identifier.issn0168-3659-
dc.identifier.urihttp://hdl.handle.net/10203/96139-
dc.description.abstractNanoparticles for cancer therapy and imaging are designed to accumulate in the diseased tissue by exploiting the Enhanced Permeability and Retention (EPR) effect. This limits their size to about 100 nm. Here, using intravital microscopy and elemental analysis, we compare the in vivo localization of particles with different geometries and demonstrate that plateloid particles preferentially accumulate within the tumor vasculature at unprecedented levels, independent of the EPR effect. In melanoma-bearing mice, 1000 x 400 nm plateloid particles adhered to the tumor vasculature at about 5% and 10% of the injected dose per gram organ (ID/g) for untargeted and RGD-targeted particles respectively, and exhibited the highest tumor-to-liver accumulation ratios (0.22 and 0.35). Smaller and larger plateloid particles, as well as cylindroid particles, were more extensively sequestered by the liver, spleen, and lungs. Plateloid particles appeared well-suited for taking advantage of hydrodynamic forces and interfacial interactions required for efficient tumoritropic accumulation, even without using specific targeting ligands. (c) 2011 Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectPOROUS SILICON MICROPARTICLES-
dc.subjectHUMAN TUMOR XENOGRAFT-
dc.subjectIN-VIVO-
dc.subjectMACROMOLECULAR THERAPEUTICS-
dc.subjectVASCULAR-PERMEABILITY-
dc.subjectDELIVERY-SYSTEM-
dc.subjectCANCER-THERAPY-
dc.subjectDRUG-DELIVERY-
dc.subjectSOLID TUMORS-
dc.subjectBLOOD-FLOW-
dc.titleRapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution-
dc.typeArticle-
dc.identifier.wosid000302605900018-
dc.identifier.scopusid2-s2.0-84857914530-
dc.type.rimsART-
dc.citation.volume158-
dc.citation.issue1-
dc.citation.beginningpage148-
dc.citation.endingpage155-
dc.citation.publicationnameJOURNAL OF CONTROLLED RELEASE-
dc.identifier.doi10.1016/j.jconrel.2011.10.021-
dc.contributor.localauthorKim, Pilhan-
dc.contributor.nonIdAuthorvan de Ven, Anne L.-
dc.contributor.nonIdAuthorHaley, O'Hara-
dc.contributor.nonIdAuthorFakhoury, Jean R.-
dc.contributor.nonIdAuthorAdriani, Giulia-
dc.contributor.nonIdAuthorSchmulen, Jeffrey-
dc.contributor.nonIdAuthorMoloney, Padraig-
dc.contributor.nonIdAuthorHussain, Fazle-
dc.contributor.nonIdAuthorFerrari, Mauro-
dc.contributor.nonIdAuthorLiu, Xuewu-
dc.contributor.nonIdAuthorDecuzzi, Paolo-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorNanoparticles-
dc.subject.keywordAuthorSize and shape-
dc.subject.keywordAuthorBiodistribution-
dc.subject.keywordAuthorTumor accumulation-
dc.subject.keywordAuthorRational design-
dc.subject.keywordAuthorIntravital microscopy-
dc.subject.keywordPlusPOROUS SILICON MICROPARTICLES-
dc.subject.keywordPlusHUMAN TUMOR XENOGRAFT-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusMACROMOLECULAR THERAPEUTICS-
dc.subject.keywordPlusVASCULAR-PERMEABILITY-
dc.subject.keywordPlusDELIVERY-SYSTEM-
dc.subject.keywordPlusCANCER-THERAPY-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusSOLID TUMORS-
dc.subject.keywordPlusBLOOD-FLOW-
Appears in Collection
NT-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 158 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0