Dopamine Signalling in Mushroom Bodies Regulates Temperature-Preference Behaviour in Drosophila

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The ability to respond to environmental temperature variation is essential for survival in animals. Flies show robust temperature-preference behaviour (TPB) to find optimal temperatures. Recently, we have shown that Drosophila mushroom body (MB) functions as a center controlling TPB. However, neuromodulators that control the TPB in MB remain unknown. To identify the functions of dopamine in TPB, we have conducted various genetic studies in Drosophila. Inhibition of dopamine biosynthesis by genetic mutations or treatment with chemical inhibitors caused flies to prefer temperatures colder than normal. We also found that dopaminergic neurons are involved in TPB regulation, as the targeted inactivation of dopaminergic neurons by expression of a potassium channel (Kir2.1) induced flies with the loss of cold avoidance. Consistently, the mutant flies for dopamine receptor gene (DopR) also showed a cold temperature preference, which was rescued by MB-specific expression of DopR. Based on these results, we concluded that dopamine in MB is a key component in the homeostatic temperature control of Drosophila. The current findings will provide important bases to understand the logic of thermosensation and temperature preference decision in Drosophila.
Publisher
PUBLIC LIBRARY SCIENCE
Issue Date
2011-03
Language
English
Article Type
Article
Keywords

MALE COURTSHIP BEHAVIOR; SYNAPTIC TRANSMISSION; TYROSINE-HYDROXYLASE; ADULT DROSOPHILA; CENTRAL COMPLEX; NERVOUS-SYSTEM; MEMORY TRACES; BODY NEUROPIL; TRP CHANNELS; MELANOGASTER

Citation

PLOS GENETICS, v.7, no.3

ISSN
1553-7390
DOI
10.1371/journal.pgen.1001346
URI
http://hdl.handle.net/10203/96028
Appears in Collection
BS-Journal Papers(저널논문)
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