DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Ki-Hyun | ko |
dc.contributor.author | Lee, Kyu-Ri | ko |
dc.contributor.author | Kim, Chun-Soo | ko |
dc.contributor.author | Park, Tae-Gwan | ko |
dc.date.accessioned | 2013-03-09T08:51:07Z | - |
dc.date.available | 2013-03-09T08:51:07Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-01 | - |
dc.identifier.citation | BIOMATERIALS, v.32, no.1, pp.176 - 184 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://hdl.handle.net/10203/95918 | - |
dc.description.abstract | Multifunctional hollow manganese oxide nanoparticles (HMON) were produced by a bio-inspired surface functionalization approach, using 3,4-dihydroxy-L-phenylalanine (DOPA) as an adhesive moiety, for cancer targeted delivery of therapeutic siRNA and simultaneous diagnosis via magnetic resonance imaging (MRI). Cationic polyethylenimine-DOPA conjugates were stably immobilized onto the surface of HMON due to the strong binding affinity of DOPA to metal oxides, as examined by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. These nanoparticles were subsequently functionalized with a therapeutic monoclonal antibody, Herceptin, to selectively target cancer cells. Confocal microscopy and MR imaging studies revealed that the surface functionalized HMON enabled the targeted detection of cancer cells in T(1)-weighted MRI as well as the efficient intracellular delivery of siRNA for cell-specific gene silencing. These nanomaterials are expected to be widely exploited as multifunctional delivery vehicles for cancer therapy and imaging applications. (C) 2010 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | Elsevier Sci Ltd | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | GENE DELIVERY | - |
dc.subject | THERAPY | - |
dc.subject | CELLS | - |
dc.subject | THERAPEUTICS | - |
dc.subject | PACLITAXEL | - |
dc.subject | MICELLES | - |
dc.subject | GLYCOL) | - |
dc.subject | AGENTS | - |
dc.subject | T-1 | - |
dc.title | Surface functionalized hollow manganese oxide nanoparticles for cancer targeted siRNA delivery and magnetic resonance imaging | - |
dc.type | Article | - |
dc.identifier.wosid | 000285217600021 | - |
dc.identifier.scopusid | 2-s2.0-78349306448 | - |
dc.type.rims | ART | - |
dc.citation.volume | 32 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 176 | - |
dc.citation.endingpage | 184 | - |
dc.citation.publicationname | BIOMATERIALS | - |
dc.contributor.localauthor | Park, Tae-Gwan | - |
dc.contributor.nonIdAuthor | Kim, Chun-Soo | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Bio-inspired | - |
dc.subject.keywordAuthor | Manganese oxide | - |
dc.subject.keywordAuthor | Nanoparticles | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
dc.subject.keywordAuthor | Small interfering RNA | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | THERAPEUTICS | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | MICELLES | - |
dc.subject.keywordPlus | GLYCOL) | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordPlus | T-1 | - |
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