Synergistic Effect of Graphene Oxide/MWCNT Films in Laser Desorption/Ionization Mass Spectrometry of Small Molecules and Tissue Imaging

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Matrix-assisted laser desorption/ionization mass spectrometry has been considered an important tool for various biochemical analyses and proteomics research. Although addition of conventional matrix efficiently supports laser desorption/ionization of analytes with minimal fragmentation, it often results In high background interference and misinterpretation of the spatial distribution of biomolecules especially in low-mass regions. Here, we show design, systematic characterization, and application of graphene oxide/multiwalled carbon nanotube-based films fabricated on solid substrates as a new matrix-free laser desorption/ionization platform. We demonstrate that the graphene oxide/multiwalled carbon nanotube double layer provides many advantages as a laser desorption/ionization substrate, such as efficient desorption/ionization of analytes with minimum fragmentation, high salt tolerance, no sweet-spots for mass signal, excellent durability against mechanical and photoagitation and prolonged exposure to ambient conditions, and applicability to tissue imaging mass spectrometry. This platform will be widely used as an important tool for mass spectrometry-based biochemical analyses because of its outstanding performance, long-term stability, and cost effectiveness.
Publisher
AMER CHEMICAL SOC
Issue Date
2011-06
Language
English
Article Type
Article
Keywords

MALDI-TOF-MS; CARBON NANOTUBES; DESORPTION-IONIZATION; GOLD NANOPARTICLES; SILICON DIOS; MATRIX; SURFACE; EXTRACTION; PEPTIDES; LIPIDS

Citation

ACS NANO, v.5, no.6, pp.4550 - 4561

ISSN
1936-0851
URI
http://hdl.handle.net/10203/95877
Appears in Collection
CH-Journal Papers(저널논문)BiS-Journal Papers(저널논문)
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