Label-free optical activation of astrocyte in vivo

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As the most abundant cell type in the central nervous system, astrocyte has been one of main research topics in neuroscience. Although various tools have been developed, at present, there is no tool that allows noninvasive activation of astrocyte in vivo without genetic or pharmacological perturbation. Here we report a noninvasive label-free optical method for physiological astrocyte activation in vivo using a femtosecond pulsed laser. We showed the laser stimulation robustly induced astrocytic calcium activation in vivo and further verified physiological relevance of the calcium increase by demonstrating astrocyte mediated vasodilation in the brain. This novel optical method will facilitate noninvasive physiological study on astrocyte function. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3600774]
Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
Issue Date
2011-07
Language
English
Article Type
Article
Citation

JOURNAL OF BIOMEDICAL OPTICS, v.16, no.7

ISSN
1083-3668
DOI
10.1117/1.3600774
URI
http://hdl.handle.net/10203/95860
Appears in Collection
MSE-Journal Papers(저널논문)BiS-Journal Papers(저널논문)
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