Effect of Hydrophobic Octadecyl Groups on pH-Sensitive Aggregation Behavior of Imidazole-Containing Polyaspartammide Derivatives

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The effect of hydrophobic octadecyl groups on pH-dependent aggregation behavior of polyaspartammide derivatives was studied. A series of pH-sensitive amphiphilic polymers with different degrees of octaceylamine (018) substitution were synthesized through a successive graft reaction of octaceylamine, O-(2-aminoethyl)-O'-methylpolyethylene glycol, and 1-(3-aminopropyl)imidazole on polysuccinimide. Micelle-like nano-aggregates were formed in aqueous solution at pH > 6.8 and they showed different pH dependent aggregation behavior according to degree of substitution (DS) of the hydrophobic 018 chains. These polymers will have a potential application as carriers for pH-sensitive drug release in anticancer or intracellular delivery systems.
Publisher
Amer Scientific Publishers
Issue Date
2010-10
Language
English
Article Type
Article; Proceedings Paper
Keywords

DRUG-DELIVERY; POLY(ASPARTIC ACID); COPOLYMERS; POLY(CAPROLACTONE); POLYCONDENSATION; ASPARTAMIDE); FLUORESCENCE; CARRIER

Citation

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.10, no.10, pp.6986 - 6991

ISSN
1533-4880
DOI
10.1166/jnn.2010.2987
URI
http://hdl.handle.net/10203/95821
Appears in Collection
CBE-Journal Papers(저널논문)
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