Enhancement of xylitol production by attenuation of intracellular xylitol dehydrogenase activity in Candida tropicalis

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dc.contributor.authorKo, Byoung-Samko
dc.contributor.authorKim, Dong-Minko
dc.contributor.authorYoon, Byoung-Hoonko
dc.contributor.authorBai, Sukko
dc.contributor.authorLee, Hyeon-Yongko
dc.contributor.authorKim, Jung-Hoeko
dc.contributor.authorKim, Il-Chulko
dc.date.accessioned2013-03-09T07:59:23Z-
dc.date.available2013-03-09T07:59:23Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2011-06-
dc.identifier.citationBIOTECHNOLOGY LETTERS, v.33, no.6, pp.1209 - 1213-
dc.identifier.issn0141-5492-
dc.identifier.urihttp://hdl.handle.net/10203/95801-
dc.description.abstractTo construct Candida tropicalis strains that produce a high yield of xylitol with no requirement for co-substrates, we engineered the yeast with an attenuated xylitol dehydrogenase (XDH) and then assessed the efficiency of xylitol production The mutants, strains XDH-5 (with only one copy of the XDH gene), and ARSdR-16 (with a mutated XDH gene) showed 70 and 40% of wild type (WT) XDH activity, respectively. Conversions of xylose to xylitol by WT, XDH-5, and ARSdR-16 were 62, 64, and 75%, respectively, with productivities of 0.52, 0.54, and 0.62 g l(-1) h(-1), respectively. The ARSdR-16 mutant strain produced xylitol with high yield and high productivity in a simple process that required no co-substrates, such as glycerol. This strain represents a promising alternative for efficient and cost-effective xylitol production.-
dc.languageEnglish-
dc.publisherSPRINGER-
dc.subjectGENE-DISRUPTED MUTANT-
dc.subjectD-XYLOSE-
dc.subjectYIELD-
dc.titleEnhancement of xylitol production by attenuation of intracellular xylitol dehydrogenase activity in Candida tropicalis-
dc.typeArticle-
dc.identifier.wosid000291655200019-
dc.identifier.scopusid2-s2.0-79955942312-
dc.type.rimsART-
dc.citation.volume33-
dc.citation.issue6-
dc.citation.beginningpage1209-
dc.citation.endingpage1213-
dc.citation.publicationnameBIOTECHNOLOGY LETTERS-
dc.contributor.localauthorKim, Jung-Hoe-
dc.contributor.nonIdAuthorKo, Byoung-Sam-
dc.contributor.nonIdAuthorKim, Dong-Min-
dc.contributor.nonIdAuthorBai, Suk-
dc.contributor.nonIdAuthorLee, Hyeon-Yong-
dc.contributor.nonIdAuthorKim, Il-Chul-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorCandida tropicalis-
dc.subject.keywordAuthorEnzyme engineering-
dc.subject.keywordAuthorFermentation-
dc.subject.keywordAuthorXylitol-
dc.subject.keywordAuthorXylitol dehydrogenase-
dc.subject.keywordPlusGENE-DISRUPTED MUTANT-
dc.subject.keywordPlusD-XYLOSE-
dc.subject.keywordPlusYIELD-
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