DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Eunji | ko |
dc.contributor.author | Song, Ji-Joon | ko |
dc.date.accessioned | 2013-03-09T06:42:14Z | - |
dc.date.available | 2013-03-09T06:42:14Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-11 | - |
dc.identifier.citation | GENES & DEVELOPMENT, v.25, no.21, pp.2223 - 2226 | - |
dc.identifier.issn | 0890-9369 | - |
dc.identifier.uri | http://hdl.handle.net/10203/95624 | - |
dc.description.abstract | Histone methylations are highly regulated by site-specific histone methyltransferases and demethylases. In this issue of Genes & Development, Sengoku and Yokoyama (pp. 2266-2277) demonstrate that a novel Zn-binding domain and the Jumonji domain of UTX/KDM6A (Lys demethylase 6A) recognize histone H3 and together function as a substrate specificity determinant for H3K27 demethylation. This study demonstrates the mechanism of site-specific demethylation by UTX/KDM6A and implicates that histone demethylases use diverse methods to accomplish target specificity. | - |
dc.language | English | - |
dc.publisher | Cold Spring Harbor Lab Press | - |
dc.subject | METHYLTRANSFERASE COMPLEX | - |
dc.subject | METHYLATION | - |
dc.subject | JMJD2A | - |
dc.subject | RECOGNITION | - |
dc.subject | UTX | - |
dc.title | Diverse ways to be specific: a novel Zn-binding domain confers substrate specificity to UTX/KDM6A histone H3 Lys 27 demethylase | - |
dc.type | Article | - |
dc.identifier.wosid | 000296743700001 | - |
dc.identifier.scopusid | 2-s2.0-84861813539 | - |
dc.type.rims | ART | - |
dc.citation.volume | 25 | - |
dc.citation.issue | 21 | - |
dc.citation.beginningpage | 2223 | - |
dc.citation.endingpage | 2226 | - |
dc.citation.publicationname | GENES & DEVELOPMENT | - |
dc.contributor.localauthor | Song, Ji-Joon | - |
dc.contributor.nonIdAuthor | Kim, Eunji | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | epigenetics | - |
dc.subject.keywordAuthor | UTX/KDM6A | - |
dc.subject.keywordAuthor | histone demethylase | - |
dc.subject.keywordAuthor | jumonji domain | - |
dc.subject.keywordAuthor | crystal structure | - |
dc.subject.keywordAuthor | H3K27 methylation | - |
dc.subject.keywordPlus | METHYLTRANSFERASE COMPLEX | - |
dc.subject.keywordPlus | METHYLATION | - |
dc.subject.keywordPlus | JMJD2A | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | UTX | - |
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