Lung Myeloid Dendritic Cells Coordinately Induce T(H)1 and T(H)17 Responses in Human Emphysema

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dc.contributor.authorShan, Mingko
dc.contributor.authorCheng, Han-Fangko
dc.contributor.authorSong, Li-zhenko
dc.contributor.authorRoberts, Luzko
dc.contributor.authorGreen, Lindako
dc.contributor.authorHacken-Bitar, Joanko
dc.contributor.authorHuh, Josephko
dc.contributor.authorBakaeen, Faisalko
dc.contributor.authorCoxson, Harvey O.ko
dc.contributor.authorStorness-Bliss, Claudineko
dc.contributor.authorRamchandani, Maheshko
dc.contributor.authorLee, Seung-Hyoko
dc.contributor.authorCorry, David B.ko
dc.contributor.authorKheradmand, Farrahko
dc.date.accessioned2013-03-09T06:29:52Z-
dc.date.available2013-03-09T06:29:52Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2009-10-
dc.identifier.citationSCIENCE TRANSLATIONAL MEDICINE, v.1, no.4-
dc.identifier.issn1946-6234-
dc.identifier.urihttp://hdl.handle.net/10203/95597-
dc.description.abstractExposure to tobacco smoke activates innate and adaptive immune responses that in long-term smokers have been linked to diseases of the lungs, cardiovascular system, joints, and other organs. The destruction of lung tissue that underlies smoking-induced emphysema has been associated with T helper 1 cells that recognize the matrix protein elastin. Factors that result in the development of such autoreactive T cells in smokers remain unknown but are crucial for further understanding the pathogenesis of systemic inflammatory diseases in smokers. Here, we show that lung myeloid dendritic cells were sufficient to induce T helper 1 and T helper 17 responses in CD4 T cells. T helper 1 and 17 cells are invariably present in lungs from patients with emphysema but not in lungs from normal individuals. Interleukin-17A, a canonical T helper 17 cytokine, enhanced secretion of CCL20, a chemoattractant for dendritic cells, and matrix metalloproteinase 12, a potent elastolytic proteinase, from lung macrophages. Thus, although diverse lung factors potentially contribute to T helper effector differentiation in vivo, lung myeloid dendritic cells direct the generation of pathogenic T cells and support a feedback mechanism that sustains both inflammatory cell recruitment and lung destruction. This mechanism may underlie disease in other elastin-rich organs and tissues.-
dc.languageEnglish-
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE-
dc.subjectOBSTRUCTIVE PULMONARY-DISEASE-
dc.subjectSMOKE-INDUCED EMPHYSEMA-
dc.subjectREGULATORY T-CELLS-
dc.subjectELASTIN-DERIVED PEPTIDES-
dc.subjectCIGARETTE-SMOKING-
dc.subjectTOBACCO SMOKING-
dc.subjectTH17 CELLS-
dc.subjectINFLAMMATION-
dc.subjectCYTOKINES-
dc.subjectIL-17-
dc.titleLung Myeloid Dendritic Cells Coordinately Induce T(H)1 and T(H)17 Responses in Human Emphysema-
dc.typeArticle-
dc.identifier.wosid000277197200003-
dc.identifier.scopusid2-s2.0-77954664861-
dc.type.rimsART-
dc.citation.volume1-
dc.citation.issue4-
dc.citation.publicationnameSCIENCE TRANSLATIONAL MEDICINE-
dc.identifier.doi10.1126/scitranlsmed.3000154-
dc.contributor.localauthorLee, Seung-Hyo-
dc.contributor.nonIdAuthorShan, Ming-
dc.contributor.nonIdAuthorCheng, Han-Fang-
dc.contributor.nonIdAuthorSong, Li-zhen-
dc.contributor.nonIdAuthorRoberts, Luz-
dc.contributor.nonIdAuthorGreen, Linda-
dc.contributor.nonIdAuthorHacken-Bitar, Joan-
dc.contributor.nonIdAuthorHuh, Joseph-
dc.contributor.nonIdAuthorBakaeen, Faisal-
dc.contributor.nonIdAuthorCoxson, Harvey O.-
dc.contributor.nonIdAuthorStorness-Bliss, Claudine-
dc.contributor.nonIdAuthorRamchandani, Mahesh-
dc.contributor.nonIdAuthorCorry, David B.-
dc.contributor.nonIdAuthorKheradmand, Farrah-
dc.type.journalArticleArticle-
dc.subject.keywordPlusOBSTRUCTIVE PULMONARY-DISEASE-
dc.subject.keywordPlusSMOKE-INDUCED EMPHYSEMA-
dc.subject.keywordPlusREGULATORY T-CELLS-
dc.subject.keywordPlusELASTIN-DERIVED PEPTIDES-
dc.subject.keywordPlusCIGARETTE-SMOKING-
dc.subject.keywordPlusTOBACCO SMOKING-
dc.subject.keywordPlusTH17 CELLS-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusCYTOKINES-
dc.subject.keywordPlusIL-17-
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