Reduction of Postsurgical Adhesion Formation with CM-Chitosan Hydrogel Barriers Prepared by Using gamma-Irradiation

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To evaluate the efficiency of carboxymethylchitosan (CM-chitosan)-based hydrogels as barriers for reducing postsurgical adhesions, CM-chitosan was synthesized to simplify the hydrogel-making process, and the CM-chitosan solutions were cross-linked by using gamma-ray irradiation to create the desired hydrogels instead of using chemical cross-linking reagents. The prepared CM-chitosan hydrogels were characterized by a FTIR spectroscopy, swelling behavior, gel-fraction content,and mechanical property such as gel strength of a hydrogel and the results showed a good swelling behavior and mechanical properties. Also, the radiation-induced CM-chitosan hydrogels significantly reduced and inhibited the postsurgical adhesions in the rat models. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 116: 3682-3687, 2010
Publisher
JOHN WILEY & SONS INC
Issue Date
2010-06
Language
English
Article Type
Article
Keywords

POSTOPERATIVE INTRAPERITONEAL ADHESIONS; CARBOXYMETHYLATED CHITIN DERIVATIVES; POLY(VINYL ALCOHOL); PREVENTION; MEMBRANE; POLYMERS

Citation

JOURNAL OF APPLIED POLYMER SCIENCE, v.116, no.6, pp.3682 - 3687

ISSN
0021-8995
DOI
10.1002/app.31945
URI
http://hdl.handle.net/10203/95586
Appears in Collection
CBE-Journal Papers(저널논문)
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