Antitumor activity of methylan polysaccharide derivatives

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Methylan polysaccharide derivatives were prepared by dialkylaminoalkylation and reductive amination followed by quaternization. Their antitumor activity was investigated and a relationship between structure and activity is suggested. For quaternized DEAE-methylan at only 75 mu g ml(-1), tumor cell proliferation was suppressed by 58-84% in three cell lines tested in the order Colo < Hela < HepG2.
Publisher
SPRINGER
Issue Date
2010-07
Language
English
Article Type
Article
Keywords

MEDICINAL MUSHROOMS; CAPACITY

Citation

BIOTECHNOLOGY LETTERS, v.32, pp.891 - 895

ISSN
0141-5492
DOI
10.1007/s10529-010-0246-4
URI
http://hdl.handle.net/10203/95580
Appears in Collection
BS-Journal Papers(저널논문)
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