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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

Di- and Triblock siRNA-PEG Copolymers: PEG Density Effect of Polyelectrolyte Complexes on Cellular Uptake and Gene Silencing Efficiency

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dc.contributor.authorLee, Soo-Hyeonko
dc.contributor.authorMok, Hye-Jungko
dc.contributor.authorPark, Tae-Gwanko
dc.date.accessioned2013-03-09T03:45:54Z-
dc.date.available2013-03-09T03:45:54Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2011-03-
dc.identifier.citationMACROMOLECULAR BIOSCIENCE, v.11, no.3, pp.410 - 418-
dc.identifier.issn1616-5187-
dc.identifier.urihttp://hdl.handle.net/10203/95281-
dc.description.abstractDi- and triblock siRNA/PEG copolymers were synthesized and complexed with cationic SLN for assessing their gene silencing efficiency as a function of PEG density. A sssiRNA and a sassiRNA were separately conjugated with PEG via a disulfide linkage. AB-type diblock and ABA-type triblock copolymers were successfully prepared by stoichiometric hybridization of sssiRNA-PEG conjugate with sassiRNA and sassiRNA-PEG conjugate, respectively. The resultant di- and triblock copolymers were characterized by means of GPC and gel electrophoresis. The serum stability of siRNA in the copolymers was enhanced as compared to that of naked siRNA. Using cationic SLN as a model carrier, the PEGylation density effect of the siRNA-PEG/SLN complexes on gene silencing and cellular uptake was analyzed.-
dc.languageEnglish-
dc.publisherWILEY-BLACKWELL-
dc.subjectCOATED GOLD NANOPARTICLES-
dc.subjectCHAIN-LENGTH-
dc.subjectVEGF SIRNA-
dc.subjectPROTEIN ADSORPTION-
dc.subjectFUSOGENIC PEPTIDE-
dc.subjectAQUEOUS-SOLUTION-
dc.subjectINTERFERING RNA-
dc.subjectDELIVERY-
dc.subjectCONJUGATE-
dc.subjectMICELLES-
dc.titleDi- and Triblock siRNA-PEG Copolymers: PEG Density Effect of Polyelectrolyte Complexes on Cellular Uptake and Gene Silencing Efficiency-
dc.typeArticle-
dc.identifier.wosid000288034800011-
dc.identifier.scopusid2-s2.0-79952075437-
dc.type.rimsART-
dc.citation.volume11-
dc.citation.issue3-
dc.citation.beginningpage410-
dc.citation.endingpage418-
dc.citation.publicationnameMACROMOLECULAR BIOSCIENCE-
dc.identifier.doi10.1002/mabi.201000347-
dc.contributor.localauthorPark, Tae-Gwan-
dc.contributor.nonIdAuthorMok, Hye-Jung-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorconjugates-
dc.subject.keywordAuthorgene silencing-
dc.subject.keywordAuthorintracellular uptake-
dc.subject.keywordAuthorpoly(ethylene glycol) (PEG)-
dc.subject.keywordAuthorsmall interfering RNA (siRNA)-
dc.subject.keywordPlusCOATED GOLD NANOPARTICLES-
dc.subject.keywordPlusCHAIN-LENGTH-
dc.subject.keywordPlusVEGF SIRNA-
dc.subject.keywordPlusPROTEIN ADSORPTION-
dc.subject.keywordPlusFUSOGENIC PEPTIDE-
dc.subject.keywordPlusAQUEOUS-SOLUTION-
dc.subject.keywordPlusINTERFERING RNA-
dc.subject.keywordPlusDELIVERY-
dc.subject.keywordPlusCONJUGATE-
dc.subject.keywordPlusMICELLES-
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