Biodegradable luminescent porous silicon nanoparticles for in vivo applications

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Nanomaterials that can circulate in the body hold great potential to diagnose and treat disease(1-4). For such applications, it is important that the nanomaterials be harmlessly eliminated from the body in a reasonable period of time after they carry out their diagnostic or therapeutic function. Despite efforts to improve their targeting efficiency, significant quantities of systemically administered nanomaterials are cleared by the mononuclear phagocytic system before finding their targets, increasing the likelihood of unintended acute or chronic toxicity. However, there has been little effort to engineer the self-destruction of errant nanoparticles into non-toxic, systemically eliminated products. Here, we present luminescent porous silicon nanoparticles (LPSiNPs) that can carry a drug payload and of which the intrinsic near-infrared photoluminescence enables monitoring of both accumulation and degradation in vivo. Furthermore, in contrast to most optically active nanomaterials (carbon nanotubes, gold nanoparticles and quantum dots), LPSiNPs self-destruct in a mouse model into renally cleared components in a relatively short period of time with no evidence of toxicity. As a preliminary in vivo application, we demonstrate tumour imaging using dextran-coated LPSiNPs (D-LPSiNPs). These results demonstrate a new type of multifunctional nanostructure with a low-toxicity degradation pathway for in vivo applications.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2009-04
Language
English
Article Type
Article
Keywords

SEMICONDUCTOR QUANTUM DOTS; MAGNETIC NANOPARTICLES; CARBON NANOTUBES; CELLS; MICE; NANOCRYSTALS; FABRICATION; CLEARANCE; ACID

Citation

NATURE MATERIALS, v.8, no.4, pp.331 - 336

ISSN
1476-1122
DOI
10.1038/NMAT2398
URI
http://hdl.handle.net/10203/95121
Appears in Collection
BiS-Journal Papers(저널논문)
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