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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

H2S Signals Through Protein S-Sulfhydration

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dc.contributor.authorMustafa, Asif K.ko
dc.contributor.authorGadalla, Moataz M.ko
dc.contributor.authorSen, Nilkanthako
dc.contributor.authorKim, Seyunko
dc.contributor.authorMu, Weitongko
dc.contributor.authorGazi, Sadia K.ko
dc.contributor.authorBarrow, Roxanne K.ko
dc.contributor.authorYang, Guangdongko
dc.contributor.authorWang, Ruiko
dc.contributor.authorSnyder, Solomon H.ko
dc.date.accessioned2013-03-08T21:34:43Z-
dc.date.available2013-03-08T21:34:43Z-
dc.date.created2012-03-19-
dc.date.created2012-03-19-
dc.date.issued2009-11-
dc.identifier.citationSCIENCE SIGNALING, v.2, no.96-
dc.identifier.issn1937-9145-
dc.identifier.urihttp://hdl.handle.net/10203/94368-
dc.description.abstractHydrogen sulfide (H2S), a messenger molecule generated by cystathionine gamma-lyase, acts as a physiologic vasorelaxant. Mechanisms whereby H2S signals have been elusive. We now show that H2S physiologically modifies cysteines in a large number of proteins by S-sulfhydration. About 10 to 25% of many liver proteins, including actin, tubulin, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), are sulfhydrated under physiological conditions. Sulfhydration augments GAPDH activity and enhances actin polymerization. Sulfhydration thus appears to be a physiologic posttranslational modification for proteins.-
dc.languageEnglish-
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE-
dc.subjectHYDROGEN-SULFIDE-
dc.subjectNITRIC-OXIDE-
dc.subjectNITROSYLATION-
dc.subjectVASORELAXANT-
dc.subjectCYSTEINE-
dc.subjectLIVER-
dc.subjectMICE-
dc.titleH2S Signals Through Protein S-Sulfhydration-
dc.typeArticle-
dc.identifier.wosid000275644900006-
dc.identifier.scopusid2-s2.0-74949103637-
dc.type.rimsART-
dc.citation.volume2-
dc.citation.issue96-
dc.citation.publicationnameSCIENCE SIGNALING-
dc.identifier.doi10.1126/scisignal.2000464-
dc.contributor.localauthorKim, Seyun-
dc.contributor.nonIdAuthorMustafa, Asif K.-
dc.contributor.nonIdAuthorGadalla, Moataz M.-
dc.contributor.nonIdAuthorSen, Nilkantha-
dc.contributor.nonIdAuthorMu, Weitong-
dc.contributor.nonIdAuthorGazi, Sadia K.-
dc.contributor.nonIdAuthorBarrow, Roxanne K.-
dc.contributor.nonIdAuthorYang, Guangdong-
dc.contributor.nonIdAuthorWang, Rui-
dc.contributor.nonIdAuthorSnyder, Solomon H.-
dc.type.journalArticleArticle-
dc.subject.keywordPlusHYDROGEN-SULFIDE-
dc.subject.keywordPlusNITRIC-OXIDE-
dc.subject.keywordPlusNITROSYLATION-
dc.subject.keywordPlusVASORELAXANT-
dc.subject.keywordPlusCYSTEINE-
dc.subject.keywordPlusLIVER-
dc.subject.keywordPlusMICE-
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