DC Field | Value | Language |
---|---|---|
dc.contributor.author | Neutzner, Albert | ko |
dc.contributor.author | Neutzner, Melanie | ko |
dc.contributor.author | Benischke, Anne-Sophie | ko |
dc.contributor.author | Ryu, Seung_Wook | ko |
dc.contributor.author | Frank, Stephan | ko |
dc.contributor.author | Youle, Richard J. | ko |
dc.contributor.author | Karbowski, Mariusz | ko |
dc.date.accessioned | 2013-03-08T18:44:06Z | - |
dc.date.available | 2013-03-08T18:44:06Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.citation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.286, no.10, pp.8633 - 8643 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/10203/93942 | - |
dc.description.abstract | To identify novel regulators of endoplasmic reticulum (ER)-linked protein degradation and ER function, we determined the entire inventory of membrane-spanning RING finger E3 ubiquitin ligases localized to the ER. We identified 24 ER membrane-anchored ubiquitin ligases and found Nixin/ZNRF4 to be central for the regulation of calnexin turnover. Ectopic expression of wild type Nixin induced a dramatic down-regulation of the ER-localized chaperone calnexin that was prevented by inactivation of the Nixin RING domain. Importantly, Nixin physically interacts with calnexin in a glycosylation-independent manner, induces calnexin ubiquitination, and p97-dependent degradation, indicating an ER-associated degradation-like mechanism of calnexin turnover. | - |
dc.language | English | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.subject | TRANSMEMBRANE CONDUCTANCE REGULATOR | - |
dc.subject | QUALITY-CONTROL | - |
dc.subject | UBIQUITIN | - |
dc.subject | LIGASE | - |
dc.subject | DEGRADATION | - |
dc.subject | PROTEOMICS | - |
dc.subject | MEDIATORS | - |
dc.subject | PATHWAYS | - |
dc.subject | TOPOLOGY | - |
dc.subject | DATABASE | - |
dc.title | A Systematic Search for Endoplasmic Reticulum (ER) Membrane-associated RING Finger Proteins Identifies Nixin/ZNRF4 as a Regulator of Calnexin Stability and ER Homeostasis | - |
dc.type | Article | - |
dc.identifier.wosid | 000288013300089 | - |
dc.identifier.scopusid | 2-s2.0-79953142340 | - |
dc.type.rims | ART | - |
dc.citation.volume | 286 | - |
dc.citation.issue | 10 | - |
dc.citation.beginningpage | 8633 | - |
dc.citation.endingpage | 8643 | - |
dc.citation.publicationname | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.identifier.doi | 10.1074/jbc.M110.197459 | - |
dc.contributor.nonIdAuthor | Neutzner, Albert | - |
dc.contributor.nonIdAuthor | Neutzner, Melanie | - |
dc.contributor.nonIdAuthor | Benischke, Anne-Sophie | - |
dc.contributor.nonIdAuthor | Frank, Stephan | - |
dc.contributor.nonIdAuthor | Youle, Richard J. | - |
dc.contributor.nonIdAuthor | Karbowski, Mariusz | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TRANSMEMBRANE CONDUCTANCE REGULATOR | - |
dc.subject.keywordPlus | QUALITY-CONTROL | - |
dc.subject.keywordPlus | UBIQUITIN | - |
dc.subject.keywordPlus | LIGASE | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | PROTEOMICS | - |
dc.subject.keywordPlus | MEDIATORS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | TOPOLOGY | - |
dc.subject.keywordPlus | DATABASE | - |
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