DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, J | ko |
dc.contributor.author | Buglass, Alan J | ko |
dc.contributor.author | Lee, Eok Kyun | ko |
dc.date.accessioned | 2013-03-08T18:38:53Z | - |
dc.date.available | 2013-03-08T18:38:53Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-07 | - |
dc.identifier.citation | JOURNAL OF SOLUTION CHEMISTRY, v.39, pp.943 - 958 | - |
dc.identifier.issn | 0095-9782 | - |
dc.identifier.uri | http://hdl.handle.net/10203/93933 | - |
dc.description.abstract | We investigate various topological and energy parameters from the protein native structure and find combinations of some parameters that are well correlated with the rate of folding/unfolding. For folding, the topological quantity that combines the clustering coefficient and the long-range order (or total contact distance/contact order) has a high correlation with the folding rate, expressed as ln k (F) , obtained from standard experimental conditions. For unfolding, a combination of the impact of edge removal, obtained from the protein structure, and the stability of the native protein structure, as expressed by the free energy change Delta G, gives a good correlation with unfolding rate, ln k (U) . | - |
dc.language | English | - |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | - |
dc.subject | TRANSITION-STATE PLACEMENT | - |
dc.subject | SINGLE-DOMAIN PROTEINS | - |
dc.subject | AQUEOUS-SOLUTIONS | - |
dc.subject | CONTACT ORDER | - |
dc.subject | AMINO-ACIDS | - |
dc.subject | SH3 DOMAIN | - |
dc.subject | ENTHALPIC INTERACTION | - |
dc.subject | COMPLEX NETWORKS | - |
dc.subject | RATE PREDICTION | - |
dc.subject | 4-HELIX BUNDLE | - |
dc.title | Topological Quantities Determining the Folding/Unfolding Rate of Two-state Folding Proteins | - |
dc.type | Article | - |
dc.identifier.wosid | 000280803000003 | - |
dc.identifier.scopusid | 2-s2.0-77958043887 | - |
dc.type.rims | ART | - |
dc.citation.volume | 39 | - |
dc.citation.beginningpage | 943 | - |
dc.citation.endingpage | 958 | - |
dc.citation.publicationname | JOURNAL OF SOLUTION CHEMISTRY | - |
dc.identifier.doi | 10.1007/s10953-010-9556-3 | - |
dc.contributor.localauthor | Buglass, Alan J | - |
dc.contributor.localauthor | Lee, Eok Kyun | - |
dc.contributor.nonIdAuthor | Jung, J | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Protein folding | - |
dc.subject.keywordAuthor | Contact order | - |
dc.subject.keywordAuthor | Long-range order | - |
dc.subject.keywordAuthor | Total contact distance | - |
dc.subject.keywordAuthor | Clustering coefficient | - |
dc.subject.keywordAuthor | Impact of edge removal | - |
dc.subject.keywordPlus | TRANSITION-STATE PLACEMENT | - |
dc.subject.keywordPlus | SINGLE-DOMAIN PROTEINS | - |
dc.subject.keywordPlus | AQUEOUS-SOLUTIONS | - |
dc.subject.keywordPlus | CONTACT ORDER | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | SH3 DOMAIN | - |
dc.subject.keywordPlus | ENTHALPIC INTERACTION | - |
dc.subject.keywordPlus | COMPLEX NETWORKS | - |
dc.subject.keywordPlus | RATE PREDICTION | - |
dc.subject.keywordPlus | 4-HELIX BUNDLE | - |
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