Optimization of transdermal delivery using magainin pore-forming peptide

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The skin's outer layer, stratum corneum, which is a thin tissue containing multilamellar lipid bilayers, is the main barrier to drug delivery through the skin. To increase skin permeability, our previous work has shown large enhancement of transdermal permeation using a pore-forming peptide, magainin, which was formulated with N-lauroyl sarcosine (NLS) in 50% ethanol-in-PBS. Mechanistic analysis suggested that magainin and NLS can increase skin permeability by disrupting stratum corneum lipid structure. In this study, our goal was to improve conditions that increase skin permeability by magainin by further optimizing the pretreatment time and concentration of magainin exposure. We found that skin permeability increased with increasing pretreatment time. Skin permeability also increased with increasing magainin concentration up to 1 mM, but was reduced at a magainin concentration of 2 mM. Enhancement of skin permeability to fluorescein (332 Da) up to 35-fold was observed. In contrast, this formulation did not enhance skin permeability to larger molecules, such as calcein (623 Da) and clextran (3000 Da). (c) 2007 Elsevier Ltd. All rights reserved.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Issue Date
2008
Language
English
Article Type
Article; Proceedings Paper
Keywords

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Citation

JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS, v.69, no.5-6, pp.1560 - 1563

ISSN
0022-3697
DOI
10.1016/j.jpcs.2007.10.138
URI
http://hdl.handle.net/10203/93144
Appears in Collection
CBE-Journal Papers(저널논문)
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