DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jeong Ho | ko |
dc.contributor.author | Lee, Jinu | ko |
dc.contributor.author | Choi, Kyu Yeong | ko |
dc.contributor.author | Hepp, Regine | ko |
dc.contributor.author | Lee, Jae-Youn | ko |
dc.contributor.author | Lim, Mi Kyung | ko |
dc.contributor.author | Chatani-Hinze, Mayumi | ko |
dc.contributor.author | Roche, Paul A. | ko |
dc.contributor.author | Kim, Dong Goo | ko |
dc.contributor.author | Ahn, Young Soo | ko |
dc.contributor.author | Kim, Chul Hoon | ko |
dc.contributor.author | Roche, Katherine W. | ko |
dc.date.accessioned | 2013-03-08T12:58:36Z | - |
dc.date.available | 2013-03-08T12:58:36Z | - |
dc.date.created | 2012-10-14 | - |
dc.date.created | 2012-10-14 | - |
dc.date.issued | 2008-08 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.105, no.34, pp.12575 - 12580 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/93067 | - |
dc.description.abstract | Metabotropic glutamate receptors (mGluRs) 1-8 are G protein-coupled receptors (GPCRs) that modulate excitatory neurotransmission, neurotransmitter release, and synaptic plasticity. PKC regulates many aspects of mGluR function, including protein-protein interactions, Ca2+ signaling, and receptor desensitization. However, the mechanisms by which PKC regulates mGluR function are poorly understood. We have now identified calmodulin (CaM) as a dynamic regulator of mGluR5 trafficking. We show that the major PKC phosphorylation site on the intracellular C terminus of mGluR5 is serine 901 (S901), and phosphorylation of this residue is up-regulated in response to both receptor and PKC activation. In addition, S901 phosphorylation inhibits mGluR5 binding to CaM, decreasing mGluR5 surface expression. Furthermore, blocking PKC phosphorylation of mGluR5 on S901 dramatically affects mGluR5 signaling by prolonging Ca2+ oscillations. Thus, our data demonstrate that mGluR5 activation triggers phosphorylation of S901, thereby directly linking PKC phosphorylation, CaM binding, receptor trafficking, and downstream signaling. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | NMDA RECEPTOR | - |
dc.subject | ALPHA-ACTININ | - |
dc.subject | NR1 SUBUNIT | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | BINDING | - |
dc.subject | CALCIUM | - |
dc.subject | DOMAIN | - |
dc.subject | INACTIVATION | - |
dc.subject | CA2+/CALMODULIN | - |
dc.title | Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5 | - |
dc.type | Article | - |
dc.identifier.wosid | 000258905700085 | - |
dc.identifier.scopusid | 2-s2.0-50449083523 | - |
dc.type.rims | ART | - |
dc.citation.volume | 105 | - |
dc.citation.issue | 34 | - |
dc.citation.beginningpage | 12575 | - |
dc.citation.endingpage | 12580 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.0712033105 | - |
dc.contributor.localauthor | Lee, Jeong Ho | - |
dc.contributor.nonIdAuthor | Lee, Jinu | - |
dc.contributor.nonIdAuthor | Choi, Kyu Yeong | - |
dc.contributor.nonIdAuthor | Hepp, Regine | - |
dc.contributor.nonIdAuthor | Lee, Jae-Youn | - |
dc.contributor.nonIdAuthor | Lim, Mi Kyung | - |
dc.contributor.nonIdAuthor | Chatani-Hinze, Mayumi | - |
dc.contributor.nonIdAuthor | Roche, Paul A. | - |
dc.contributor.nonIdAuthor | Kim, Dong Goo | - |
dc.contributor.nonIdAuthor | Ahn, Young Soo | - |
dc.contributor.nonIdAuthor | Kim, Chul Hoon | - |
dc.contributor.nonIdAuthor | Roche, Katherine W. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | phosphorylation | - |
dc.subject.keywordAuthor | protein kinase C | - |
dc.subject.keywordAuthor | receptor trafficking | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | NMDA RECEPTOR | - |
dc.subject.keywordPlus | ALPHA-ACTININ | - |
dc.subject.keywordPlus | NR1 SUBUNIT | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | INACTIVATION | - |
dc.subject.keywordPlus | CA2+/CALMODULIN | - |
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