DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, HeungKyu | ko |
dc.contributor.author | Iwasaki, Akiko | ko |
dc.date.accessioned | 2013-03-08T12:02:40Z | - |
dc.date.available | 2013-03-08T12:02:40Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-02 | - |
dc.identifier.citation | CURRENT OPINION IN IMMUNOLOGY, v.20, no.1, pp.23 - 29 | - |
dc.identifier.issn | 0952-7915 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92958 | - |
dc.description.abstract | Autophagy is an ancient pathway designed to maintain cellular homeostasis by degrading long-lived proteins and organelles in the cytosol. Recent studies demonstrate that autophagy is utilized by the cells of the innate and adaptive immune systems to combat viral infections. Autophagy plays a key role in recognizing signatures of viral infection, and represents a critical effector mechanism to restrict viral replication. On the other hand, autophagosomes have been exploited by certain viruses as a niche for viral replication. Furthermore, autophagy can be used to deliver endogenous viral antigens to the MHC class 11 loading compartment, allowing activation of CD4 T cells. In this review, we describe recent advances in the field of autophagy as it relates to innate and adaptive antiviral immune responses. | - |
dc.language | English | - |
dc.publisher | CURRENT BIOLOGY LTD | - |
dc.subject | TRANSLATION INITIATION-FACTOR | - |
dc.subject | SIMPLEX-VIRUS TYPE-1 | - |
dc.subject | CLASS-II MOLECULES | - |
dc.subject | RIG-I | - |
dc.subject | CELLULAR AUTOPHAGY | - |
dc.subject | INNATE IMMUNITY | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | CORONAVIRUS REPLICATION | - |
dc.subject | ENDOPLASMIC-RETICULUM | - |
dc.subject | VIRAL RECOGNITION | - |
dc.title | Autophagy and antiviral immunity | - |
dc.type | Article | - |
dc.identifier.wosid | 000254024300005 | - |
dc.identifier.scopusid | 2-s2.0-39149117352 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 23 | - |
dc.citation.endingpage | 29 | - |
dc.citation.publicationname | CURRENT OPINION IN IMMUNOLOGY | - |
dc.identifier.doi | 10.1016/j.coi.2008.01.001 | - |
dc.contributor.localauthor | Lee, HeungKyu | - |
dc.contributor.nonIdAuthor | Iwasaki, Akiko | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordPlus | TRANSLATION INITIATION-FACTOR | - |
dc.subject.keywordPlus | SIMPLEX-VIRUS TYPE-1 | - |
dc.subject.keywordPlus | CLASS-II MOLECULES | - |
dc.subject.keywordPlus | RIG-I | - |
dc.subject.keywordPlus | CELLULAR AUTOPHAGY | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | CORONAVIRUS REPLICATION | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | VIRAL RECOGNITION | - |
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