DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Won-il | ko |
dc.contributor.author | Do, SH | ko |
dc.contributor.author | Sohn, MH | ko |
dc.contributor.author | Yun, HS | ko |
dc.contributor.author | Kwon, OD | ko |
dc.contributor.author | Kim, TH | ko |
dc.contributor.author | Jeong, DH | ko |
dc.contributor.author | Williams, BH | ko |
dc.contributor.author | Jeong, KS | ko |
dc.date.accessioned | 2013-03-08T11:58:54Z | - |
dc.date.available | 2013-03-08T11:58:54Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-03 | - |
dc.identifier.citation | VETERINARY PATHOLOGY, v.42, no.2, pp.230 - 232 | - |
dc.identifier.issn | 0300-9858 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92954 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) with metastasis to the spleen in a Holstein cow was studied by histopathologic and immunohistochemical methods. The tumor was characterized by a pseudoglandular (acinar) pattern with an associated fibrous stroma. Individual cells often had a "hepatoid" appearance but were interspersed with scattered cells exhibiting a clear, periodic acid-Schiff (PAS)-positive cytoplasm and small eccentric nuclei. This pattern was present in nodules found in both liver and spleen. Moreover, hepatoid tumor cells were positive for alpha-fetoprotein. Immunohistochemical studies suggest that myofibroblasts were responsible for the production of fibrous septa surrounding the pseudoglandular structures of bovine HCC. In summary, our histologic and immunohistochemical findings support a diagnosis of primary HCC with splenic metastasis. Furthermore, the associated stromal response appears to be of a myofibroblast origin. The primary etiology of bovine HCC and the significance of the intralesional, PAS-positive clear cells remain undetermined. | - |
dc.language | English | - |
dc.publisher | AMER COLL VET PATHOLOGIST | - |
dc.subject | ALPHA-FETOPROTEIN | - |
dc.subject | CELLS | - |
dc.subject | LIVER | - |
dc.title | Hepatocellular carcinoma with metastasis to the spleen in a Holstein cow | - |
dc.type | Article | - |
dc.identifier.wosid | 000227300400017 | - |
dc.identifier.scopusid | 2-s2.0-20144364883 | - |
dc.type.rims | ART | - |
dc.citation.volume | 42 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 230 | - |
dc.citation.endingpage | 232 | - |
dc.citation.publicationname | VETERINARY PATHOLOGY | - |
dc.identifier.doi | 10.1354/vp.42-2-230 | - |
dc.contributor.localauthor | Jeong, Won-il | - |
dc.contributor.nonIdAuthor | Do, SH | - |
dc.contributor.nonIdAuthor | Sohn, MH | - |
dc.contributor.nonIdAuthor | Yun, HS | - |
dc.contributor.nonIdAuthor | Kwon, OD | - |
dc.contributor.nonIdAuthor | Kim, TH | - |
dc.contributor.nonIdAuthor | Jeong, DH | - |
dc.contributor.nonIdAuthor | Williams, BH | - |
dc.contributor.nonIdAuthor | Jeong, KS | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | alpha-fetoprotein | - |
dc.subject.keywordAuthor | cows | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | myofibroblast | - |
dc.subject.keywordPlus | ALPHA-FETOPROTEIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | LIVER | - |
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