DC Field | Value | Language |
---|---|---|
dc.contributor.author | Manigold, T | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Mizukoshi, E | ko |
dc.contributor.author | Mihalik, K | ko |
dc.contributor.author | Murthy, KK | ko |
dc.contributor.author | Rice, CM | ko |
dc.contributor.author | Piccirillo, CA | ko |
dc.contributor.author | Rehermann, B | ko |
dc.date.accessioned | 2013-03-08T11:31:03Z | - |
dc.date.available | 2013-03-08T11:31:03Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-06 | - |
dc.identifier.citation | BLOOD, v.107, no.11, pp.4424 - 4432 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92912 | - |
dc.description.abstract | Hepatitis C virus (HCV) poses a global health problem because it readily establishes persistent infection and a vaccine is not available. CD4(+)CD25(+) T cells have been implicated in HCV persistence because their frequency is increased in the blood of HCV-infected patients and their in vitro depletion results in increased IFN-gamma production by HCV-specific T cells. Studying a well-characterized cohort of 16 chimpanzees, the sole animal model for HCV infection, we here demonstrate that the frequency of Foxp3(+)CD4(+)CD25(+) regulatory T cells (T-Regs) and the extent of suppression was as high in spontaneously HCV-recovered chimpanzees as in persistently HCV-Infected chimpanzees. Foxp3(+)CD4(+)CD25(+) T-Regs, suppressed IFN-gamma production, expansion, and activation-induced cell death of HCV-specific T cells after recovery from HCV infection and in persistent HCV infection. Thus, T-Reg cells control HCV-specific T cells not only in persistent infection but also after recovery, where they may regulate memory T-cell responses by controlling their activation and preventing apoptosis. However, Foxp3+CD4+CD25+ TReg cells of both HCV-recovered and HCV-infected chimpanzees differed from Foxp3(+)CD4(+)CD25(+)TReg cells of HCV-naive chimpanzees in increased IL-2 responsiveness and lower T-cell receptor excision circle content, implying a history of in vivo proliferation. This result suggests that HCV infection alters the population of Foxp3+CD4+CD25+ TReg cells. | - |
dc.language | English | - |
dc.publisher | AMER SOC HEMATOLOGY | - |
dc.subject | CELLULAR IMMUNE-RESPONSES | - |
dc.subject | IN-VITRO PROLIFERATION | - |
dc.subject | REGULATORY CELLS | - |
dc.subject | VIRAL CLEARANCE | - |
dc.subject | INFECTION | - |
dc.subject | ACTIVATION | - |
dc.subject | ANTIGEN | - |
dc.subject | CD4(+) | - |
dc.subject | PERSISTENCE | - |
dc.subject | LYMPHOCYTES | - |
dc.title | Foxp3(+)CD4(+)CD25(+) T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C | - |
dc.type | Article | - |
dc.identifier.wosid | 000237877300038 | - |
dc.identifier.scopusid | 2-s2.0-33744460201 | - |
dc.type.rims | ART | - |
dc.citation.volume | 107 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 4424 | - |
dc.citation.endingpage | 4432 | - |
dc.citation.publicationname | BLOOD | - |
dc.identifier.doi | 10.1182/blood-2005-09-3903 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Manigold, T | - |
dc.contributor.nonIdAuthor | Mizukoshi, E | - |
dc.contributor.nonIdAuthor | Mihalik, K | - |
dc.contributor.nonIdAuthor | Murthy, KK | - |
dc.contributor.nonIdAuthor | Rice, CM | - |
dc.contributor.nonIdAuthor | Piccirillo, CA | - |
dc.contributor.nonIdAuthor | Rehermann, B | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CELLULAR IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | IN-VITRO PROLIFERATION | - |
dc.subject.keywordPlus | REGULATORY CELLS | - |
dc.subject.keywordPlus | VIRAL CLEARANCE | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | CD4(+) | - |
dc.subject.keywordPlus | PERSISTENCE | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
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