DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kyung Sun | ko |
dc.contributor.author | Lee, Ka Young | ko |
dc.contributor.author | Kim, So Ri | ko |
dc.contributor.author | Park, Hee Sun | ko |
dc.contributor.author | Park, Seoung Ju | ko |
dc.contributor.author | Min, Kyung Hoon | ko |
dc.contributor.author | Cho, Chung-Hyun | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Park, Ho Sung | ko |
dc.contributor.author | Lee, Yong Chul | ko |
dc.date.accessioned | 2013-03-08T10:41:56Z | - |
dc.date.available | 2013-03-08T10:41:56Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-12 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.39, no.6, pp.733 - 745 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92855 | - |
dc.description.abstract | Inflammation of the asthmatic airway is usually accompanied by increased vascular permeability and plasma exudation. Angiopoietin-1 (Ang1) has potential therapeutic applications in preventing vascular leakage. Recently, we developed a soluble, stable, and potent Ang1 variant, COMP-Ang1. COMP-Ang1 is more potent than native Angl1 in phosphorylating the tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2 receptor in lung endothelial cells. We have used a mouse model for allergic airway disease to determine effects of COMP-Ang1 on allergen-induced bronchial inflammation and airway hyper-responsiveness. These mice develop the following typical pathophysiological features of allergic air-way disease in the lungs: increased numbers of inflammatory cells of the airways, airway hyper-responsiveness, increased levels of Th2 cell cytokines (IL-4, IL-5, and IL-13), adhesion molecules (intercellular adhesion molecule-1 and vascular cell adhesion molecule-1), and chemokines (eotaxin and RANTES), and increased vascular permeability. Intravenous administration of COMP-Ang1 reduced bronchial inflammation and airway hyper-responsiveness. In addition, the increased plasma extravasation in allergic airway disease was significantly reduced by the administration of COMP-Ang1. These results suggest that COMP-Ang1 attenuates airway inflammation and hyper-responsiveness, prevents vascular leakage, and may be used as a therapeutic agent in allergic airway disease. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | BRONCHIAL-ASTHMA | - |
dc.subject | ADHESION MOLECULE-1 | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | CELL-ADHESION | - |
dc.subject | IN-VITRO | - |
dc.subject | B-CELLS | - |
dc.subject | RECEPTOR | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | PERMEABILITY | - |
dc.title | Blockade of airway inflammation and hyper-responsiveness by an angiopoietin-1 variant, COMP-Ang1 | - |
dc.type | Article | - |
dc.identifier.wosid | 000252155100007 | - |
dc.identifier.scopusid | 2-s2.0-38049141251 | - |
dc.type.rims | ART | - |
dc.citation.volume | 39 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 733 | - |
dc.citation.endingpage | 745 | - |
dc.citation.publicationname | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Lee, Kyung Sun | - |
dc.contributor.nonIdAuthor | Lee, Ka Young | - |
dc.contributor.nonIdAuthor | Kim, So Ri | - |
dc.contributor.nonIdAuthor | Park, Hee Sun | - |
dc.contributor.nonIdAuthor | Park, Seoung Ju | - |
dc.contributor.nonIdAuthor | Min, Kyung Hoon | - |
dc.contributor.nonIdAuthor | Cho, Chung-Hyun | - |
dc.contributor.nonIdAuthor | Park, Ho Sung | - |
dc.contributor.nonIdAuthor | Lee, Yong Chul | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | angiopoietin-1 | - |
dc.subject.keywordAuthor | asthma | - |
dc.subject.keywordAuthor | capillary permeability | - |
dc.subject.keywordAuthor | receptor | - |
dc.subject.keywordAuthor | Tie-2 | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | BRONCHIAL-ASTHMA | - |
dc.subject.keywordPlus | ADHESION MOLECULE-1 | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CELL-ADHESION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | PERMEABILITY | - |
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