DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, So-Ri | ko |
dc.contributor.author | Lee, Kyung-Sun | ko |
dc.contributor.author | Park, Seoung-Ju | ko |
dc.contributor.author | Min, Kyung-Hoon | ko |
dc.contributor.author | Lee, Ka-Young | ko |
dc.contributor.author | Choe, Yeong-Hun | ko |
dc.contributor.author | Hong, Sang-Hyun | ko |
dc.contributor.author | Koh, Gou-Young | ko |
dc.contributor.author | Lee, Yong-Chul | ko |
dc.date.accessioned | 2013-03-08T10:36:28Z | - |
dc.date.available | 2013-03-08T10:36:28Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-06 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.40, no.3, pp.320 - 331 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92849 | - |
dc.description.abstract | Reactive oxygen species (ROS) play a crucial role in acute lung injury. Tissue inflammation, the increased vascular permeability, and plasma exudation are cardinal features of acute lung injury. Angiopoietin-1 (Ang1) has potential therapeutic applications in preventing vascular leakage and also has beneficial effects in several inflammatory disorders. Recently developed COMP-Ang1 is more potent than native Ang1 in phosphorylating tyrosine kinase with immunoglobulin and EGF homology domain 2 receptor in endothelial cells. However, there are no data on effects and related molecular mechanisms of COMP-Ang1 on ROS-induced acute lung injury. We used hydrogen peroxide (H2O2)-inhaled mice to evaluate the. effect of COMP-Ang1 on pulmonary inflammation, bronchial hyper-responsiveness, and vascular leakage in acute lung injury. The results have revealed that VEGF expression, the levels of IL-4, TNF-alpha, IL-1 beta, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in lungs, the levels of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and NF-kappa B in nuclear protein extracts, phosphorylation of Akt, and vascular permeability were increased after inhalation of H2O2 and that the administration of COMP-Ang1 markedly reduced airway hyper-responsiveness, pulmonary inflammation, plasma extravasation, and the increases of cytokines, adhesion molecules, and VEGF in lungs treated with H2O2. We have also found that the activation of HIF-1 alpha and NF-kappa B and the increase of phosphoinositide 3-kinase activity in lung tissues after H2O2 inhalation were decreased by the administration of COMP-Ang1. These results suggest that COMP-Ang1 ameliorates ROS-induced acute lung injury through attenuating vascular leakage and modulating inflammatory mediators. | - |
dc.language | English | - |
dc.publisher | Korean Soc Med Biochemistry Molecular Biology | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | - |
dc.subject | FACTOR-KAPPA-B | - |
dc.subject | AIRWAY HYPERRESPONSIVENESS | - |
dc.subject | VASCULAR-PERMEABILITY | - |
dc.subject | ADHESION MOLECULES | - |
dc.subject | FACTOR EXPRESSION | - |
dc.subject | UP-REGULATION | - |
dc.subject | IN-VITRO | - |
dc.subject | CELLS | - |
dc.title | Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogen peroxide-induced acute lung injury | - |
dc.type | Article | - |
dc.identifier.wosid | 000257360800008 | - |
dc.identifier.scopusid | 2-s2.0-46449133564 | - |
dc.type.rims | ART | - |
dc.citation.volume | 40 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 320 | - |
dc.citation.endingpage | 331 | - |
dc.citation.publicationname | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.identifier.doi | 10.3858/emm.2008.40.3.320 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Koh, Gou-Young | - |
dc.contributor.nonIdAuthor | Kim, So-Ri | - |
dc.contributor.nonIdAuthor | Lee, Kyung-Sun | - |
dc.contributor.nonIdAuthor | Park, Seoung-Ju | - |
dc.contributor.nonIdAuthor | Min, Kyung-Hoon | - |
dc.contributor.nonIdAuthor | Lee, Ka-Young | - |
dc.contributor.nonIdAuthor | Choe, Yeong-Hun | - |
dc.contributor.nonIdAuthor | Hong, Sang-Hyun | - |
dc.contributor.nonIdAuthor | Lee, Yong-Chul | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | angiopoietin-1 | - |
dc.subject.keywordAuthor | capillary permeability | - |
dc.subject.keywordAuthor | COMP-Ang1 fusion protein | - |
dc.subject.keywordAuthor | hydrogen peroxide | - |
dc.subject.keywordAuthor | lung | - |
dc.subject.keywordAuthor | pneumonia | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | vascular endothelial growth factor A | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | AIRWAY HYPERRESPONSIVENESS | - |
dc.subject.keywordPlus | VASCULAR-PERMEABILITY | - |
dc.subject.keywordPlus | ADHESION MOLECULES | - |
dc.subject.keywordPlus | FACTOR EXPRESSION | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CELLS | - |
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