DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Won | ko |
dc.contributor.author | Moon, Sang-Ok | ko |
dc.contributor.author | Lee, Sang Yong | ko |
dc.contributor.author | Jang, Kyu Yun | ko |
dc.contributor.author | Cho, Chung-Hyun | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Yoon, Kwon-Ha | ko |
dc.contributor.author | Sung, Mi Jeong | ko |
dc.contributor.author | Kirn, Duk Hoon | ko |
dc.contributor.author | Lee, Sik | ko |
dc.contributor.author | Kang, Kyung Pyo | ko |
dc.contributor.author | Park, Sung Kwang | ko |
dc.date.accessioned | 2013-03-08T10:18:02Z | - |
dc.date.available | 2013-03-08T10:18:02Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-09 | - |
dc.identifier.citation | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v.17, no.9, pp.2474 - 2483 | - |
dc.identifier.issn | 1046-6673 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92822 | - |
dc.description.abstract | Injury to the renal microvasculature may be a major factor in the progression of renal disease; therefore, protection of endothelial cells (EC) in renal vasculature may have a therapeutic role in renal fibrosis. Recently, a soluble, stable, and potent angiopoietin-1 (Ang1) variant, cartilage oligomeric matrix protein (COMP)-Ang1, was developed. The contribution of COMP-Ang1 in renal interstitial fibrosis, however, remains to be clarified. This study investigated the effects of COMP-Ang1 on peritubular capillary EC in the renal cortex and the renal fibrogenic process that is triggered by unilateral ureteral obstruction. COMP-Ang1 preserved renal platelet-EC adhesion molecule-1- and Tie2-positive EC. Morphologic examination indicated less tubular injury and tubulointerstitial fibrosis in mice that received COMP-Ang1 than vehicle-treated mice. Interstitial type I collagen and myofibroblast accumulation were significantly suppressed by COMP-Ang1 treatment. COMP-Ang1 increased Tie2 and Akt phosphorylation in ureteral obstructed kidneys. Renal surface microvasculature and renal blood flow were higher after treatment with COMP-Ang1 than with vehicle. COMP-Ang1 treatment decreased monocyte/macrophage infiltration, tissue levels of TGF-beta 1, and Smad 2/3 phosphorylation and increased Smad 7 in the obstructed kidney. These results demonstrate that COMP-Ang1 treatment can decrease the progression of renal fibrosis in unilateral ureteral obstruction. COMP-Ang1 may be an endothelium-specific therapeutic modality in fibrotic renal disease. | - |
dc.language | English | - |
dc.publisher | AMER SOC NEPHROLOGY | - |
dc.subject | DESIGNED ANGIOPOIETIN-1 VARIANT | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | POTENTIAL ROLE | - |
dc.subject | TIE2 RECEPTOR | - |
dc.subject | BLOOD-FLOW | - |
dc.subject | EXPRESSION | - |
dc.subject | NEPHROPATHY | - |
dc.subject | PROGRESSION | - |
dc.subject | APOPTOSIS | - |
dc.subject | COMP-ANG1 | - |
dc.title | COMP-angiopoietin-1 ameliorates renal fibrosis in a unilateral ureteral obstruction model | - |
dc.type | Article | - |
dc.identifier.wosid | 000240113400017 | - |
dc.identifier.scopusid | 2-s2.0-33748065982 | - |
dc.type.rims | ART | - |
dc.citation.volume | 17 | - |
dc.citation.issue | 9 | - |
dc.citation.beginningpage | 2474 | - |
dc.citation.endingpage | 2483 | - |
dc.citation.publicationname | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | - |
dc.identifier.doi | 10.1681/ASN.2006020109 | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Kim, Won | - |
dc.contributor.nonIdAuthor | Moon, Sang-Ok | - |
dc.contributor.nonIdAuthor | Lee, Sang Yong | - |
dc.contributor.nonIdAuthor | Jang, Kyu Yun | - |
dc.contributor.nonIdAuthor | Cho, Chung-Hyun | - |
dc.contributor.nonIdAuthor | Yoon, Kwon-Ha | - |
dc.contributor.nonIdAuthor | Sung, Mi Jeong | - |
dc.contributor.nonIdAuthor | Kirn, Duk Hoon | - |
dc.contributor.nonIdAuthor | Lee, Sik | - |
dc.contributor.nonIdAuthor | Kang, Kyung Pyo | - |
dc.contributor.nonIdAuthor | Park, Sung Kwang | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DESIGNED ANGIOPOIETIN-1 VARIANT | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | POTENTIAL ROLE | - |
dc.subject.keywordPlus | TIE2 RECEPTOR | - |
dc.subject.keywordPlus | BLOOD-FLOW | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | NEPHROPATHY | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | COMP-ANG1 | - |
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