DC Field | Value | Language |
---|---|---|
dc.contributor.author | Byun, Seung-Jae | ko |
dc.contributor.author | Choi, Kyu-Sil | ko |
dc.contributor.author | Park, Sung-Hoon | ko |
dc.contributor.author | Cho, Nam-Woo | ko |
dc.contributor.author | Yoo, Chang-Hyun | ko |
dc.contributor.author | Yun, Ki-Jung | ko |
dc.contributor.author | Koh, Young-Jun | ko |
dc.contributor.author | Koh, Gou-Young | ko |
dc.contributor.author | So, Byung-Jun | ko |
dc.contributor.author | Yoon, Kwon-Ha | ko |
dc.date.accessioned | 2013-03-08T10:05:14Z | - |
dc.date.available | 2013-03-08T10:05:14Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-11 | - |
dc.identifier.citation | AMERICAN JOURNAL OF PATHOLOGY, v.171, no.5, pp.1682 - 1690 | - |
dc.identifier.issn | 0002-9440 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92801 | - |
dc.description.abstract | The present study examined the effects of cartilage oligometric matrix protein angiopoietin-1 (COMP-Ang1) on the revascularization of mice skin grafts. Full-thickness skin grafts were autotransferred into BALB/c mice. The donor grafts were soaked in COMP-Ang1 protein (50 mu g/ml, n = 10) or in bovine serum albumin (BSA) (50 mu g/ml, n = 10) dissolved in 1 ml of sterile, phosphate-buffered saline for 5 minutes before transfer. Revascularization of the grafts was monitored using an intravital microscope on postoperative days 3, 4, and 5. Morphological and immunohistochemical analyses were performed to evaluate platelet-endothelial cell adhesion molecule-1 and survivin expression and apoptotic signal in the transplanted grafts. Grafts soaked in COMP-Ang1 (COMP-Ang1 group) showed significantly increased revascularization compared with grafts soaked in BSA (BSA group) on intravital microscopy and platelet endothelial cell adhesion molecule-1 staining. The COMP Ang1 group showed a significant increase of survivin expression in the endothelial cells and a reduction of apoptotic signal in comparison to the BSA group. Therefore, we believe that COMP-Ang1 provides the therapeutic benefit of enhancing the survival of vascular endothelial cells during transplantation of skin graft. | - |
dc.language | English | - |
dc.publisher | AMER SOC INVESTIGATIVE PATHOLOGY | - |
dc.subject | DESIGNED ANGIOPOIETIN-1 VARIANT | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | BLOOD-FLOW | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | COMP-ANG1 | - |
dc.subject | RECEPTOR | - |
dc.subject | MODEL | - |
dc.subject | TIE2 | - |
dc.subject | FLAP | - |
dc.title | Cartilage oligometric matrix protein-angiopoietin-1 promotes revascularization through increased survivin expression in dermal endothelial cells of skin grafts in mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000250736100026 | - |
dc.identifier.scopusid | 2-s2.0-36348947430 | - |
dc.type.rims | ART | - |
dc.citation.volume | 171 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 1682 | - |
dc.citation.endingpage | 1690 | - |
dc.citation.publicationname | AMERICAN JOURNAL OF PATHOLOGY | - |
dc.identifier.doi | 10.2353/ajpath.2007.070142 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Koh, Gou-Young | - |
dc.contributor.nonIdAuthor | Byun, Seung-Jae | - |
dc.contributor.nonIdAuthor | Choi, Kyu-Sil | - |
dc.contributor.nonIdAuthor | Park, Sung-Hoon | - |
dc.contributor.nonIdAuthor | Cho, Nam-Woo | - |
dc.contributor.nonIdAuthor | Yoo, Chang-Hyun | - |
dc.contributor.nonIdAuthor | Yun, Ki-Jung | - |
dc.contributor.nonIdAuthor | So, Byung-Jun | - |
dc.contributor.nonIdAuthor | Yoon, Kwon-Ha | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DESIGNED ANGIOPOIETIN-1 VARIANT | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | BLOOD-FLOW | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | COMP-ANG1 | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | TIE2 | - |
dc.subject.keywordPlus | FLAP | - |
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