DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Chung-Hyun | ko |
dc.contributor.author | Kim, Kyung Eun | ko |
dc.contributor.author | Byun, Jonghoe | ko |
dc.contributor.author | Jang, Hyung-Suk | ko |
dc.contributor.author | Kim, Duk-Kyung | ko |
dc.contributor.author | Baluk, Peter | ko |
dc.contributor.author | Baffert, Fabienne | ko |
dc.contributor.author | Lee, Gyun-Min | ko |
dc.contributor.author | Mochizuki, Naoki | ko |
dc.contributor.author | Kim, Jin | ko |
dc.contributor.author | Jeon, Byeong Hwa | ko |
dc.contributor.author | McDonald, Donald M. | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.date.accessioned | 2013-03-08T08:19:41Z | - |
dc.date.available | 2013-03-08T08:19:41Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-07 | - |
dc.identifier.citation | CIRCULATION RESEARCH, v.97, no.1, pp.86 - 94 | - |
dc.identifier.issn | 0009-7330 | - |
dc.identifier.uri | http://hdl.handle.net/10203/92583 | - |
dc.description.abstract | Vascular enlargement is a characteristic feature of angiopoietin-1 (Ang1)-induced changes in adult blood vessels. However, it is unknown whether tissues having Ang1-mediated vascular enlargement have more blood flow or whether the enlargement is reversible. We have recently created a soluble, stable and potent Ang1 variant, COMP-Ang1. In the present study, we investigated the effects of varied dose and duration of COMP-Ang1 on vascular enlargement and blood flow in the tracheal microvasculature of adult mice and explored a possible mechanism of long-lasting vascular enlargement. We found that COMP-Ang1 administered by adenoviral vector induced long-lasting vascular enlargement and increased tracheal blood flow. In contrast, short-term administration of COMP-Ang1 recombinant protein induced transient vascular enlargement that spontaneously reversed within a month. In both cases, the vascular enlargement resulted from endothelial proliferation. The COMP-Ang1-induced vascular remodeling is mediated mainly through Tie2 activation. Sustained overexpression of Tie2 could participate in the maintenance of vascular changes. Together, our findings indicate that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow. | - |
dc.language | English | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | RECEPTOR TYROSINE KINASE | - |
dc.subject | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject | DESIGNED ANGIOPOIETIN-1 VARIANT | - |
dc.subject | TIE2 RECEPTOR | - |
dc.subject | OVEREXPRESSING ANGIOPOIETIN-1 | - |
dc.subject | EXPRESSION | - |
dc.subject | VESSELS | - |
dc.subject | CELLS | - |
dc.subject | MICE | - |
dc.subject | LIGAND | - |
dc.title | Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow | - |
dc.type | Article | - |
dc.identifier.wosid | 000230334900012 | - |
dc.identifier.scopusid | 2-s2.0-22144447473 | - |
dc.type.rims | ART | - |
dc.citation.volume | 97 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 86 | - |
dc.citation.endingpage | 94 | - |
dc.citation.publicationname | CIRCULATION RESEARCH | - |
dc.identifier.doi | 10.1161/01.RES.0000174093.64855.a6 | - |
dc.contributor.localauthor | Lee, Gyun-Min | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Cho, Chung-Hyun | - |
dc.contributor.nonIdAuthor | Kim, Kyung Eun | - |
dc.contributor.nonIdAuthor | Byun, Jonghoe | - |
dc.contributor.nonIdAuthor | Jang, Hyung-Suk | - |
dc.contributor.nonIdAuthor | Kim, Duk-Kyung | - |
dc.contributor.nonIdAuthor | Baluk, Peter | - |
dc.contributor.nonIdAuthor | Baffert, Fabienne | - |
dc.contributor.nonIdAuthor | Mochizuki, Naoki | - |
dc.contributor.nonIdAuthor | Kim, Jin | - |
dc.contributor.nonIdAuthor | Jeon, Byeong Hwa | - |
dc.contributor.nonIdAuthor | McDonald, Donald M. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | angiopoietin-1 | - |
dc.subject.keywordAuthor | COMP-Ang1 | - |
dc.subject.keywordAuthor | vascular enlargement | - |
dc.subject.keywordAuthor | blood flow | - |
dc.subject.keywordPlus | RECEPTOR TYROSINE KINASE | - |
dc.subject.keywordPlus | ENDOTHELIAL GROWTH-FACTOR | - |
dc.subject.keywordPlus | DESIGNED ANGIOPOIETIN-1 VARIANT | - |
dc.subject.keywordPlus | TIE2 RECEPTOR | - |
dc.subject.keywordPlus | OVEREXPRESSING ANGIOPOIETIN-1 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | VESSELS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | LIGAND | - |
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