DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Sung-Young | ko |
dc.contributor.author | Choo, Sang-Mok | ko |
dc.contributor.author | Woo, Sun-Hee | ko |
dc.contributor.author | Cho, Kwang-Hyun | ko |
dc.date.accessioned | 2013-03-08T02:48:21Z | - |
dc.date.available | 2013-03-08T02:48:21Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | PROTEIN - PROTEIN INTERACTION BOOK SERIES: ADVANCES IN BIOCHEMICAL ENGINEERING-BIOTECHNOLOGY, v.110, pp.25 - 45 | - |
dc.identifier.issn | 0724-6145 | - |
dc.identifier.uri | http://hdl.handle.net/10203/91885 | - |
dc.description.abstract | Intracellular Ca2+ dynamics of cardiac myocytes are regulated by complex mechanisms of a variety of ion channels, transporters, and exchangers. Alterations of these Ca2+ regulatory components might lead to development of cardiac diseases. To investigate the regulatory mechanisms and hidden Ca2+ dynamics we use integrative systems analysis. Herein, we briefly summarize cardiac systems biology and, within the context of cardiac systems biology, identify the functional role of key Ca2+ regulatory proteins and their influence on intracellular Ca2+ dynamics (i.e., Ca2+ transient, SR Ca2+ content, CICR gain, half-decay time) using parameter sensitivity analysis based on an experimentally validated mathematical model of mouse ventricular myocytes. In addition, we analyze the influence of the pacing period (frequency) of a stimulus current since most of the Ca2+ regulatory proteins react with different timescales. Throughout the parameter sensitivity analysis, we found that alteration of SERCA or LTCC has a more significant effect on the Ca2+ dynamics than that of RyR or NCX. In particular, for the 70% down-regulation of LTCQ the Ca2+ influx through LTCC failed to initialize the SR Ca2+ release and thereby the intracellular Ca2+ dynamics was dramatically changed. We also found that the pacing period has a significant effect on the half-decay time of the Ca2+ transients. These findings provide us with new insights into the pathophysiology of cardiac failure as well as the development of new therapeutic strategies. | - |
dc.language | English | - |
dc.publisher | SPRINGER-VERLAG BERLIN | - |
dc.subject | SODIUM-CALCIUM EXCHANGE | - |
dc.subject | RABBIT SINOATRIAL NODE | - |
dc.subject | CARDIOMYOPATHIC SYRIAN-HAMSTER | - |
dc.subject | INDUCED HEART-FAILURE | - |
dc.subject | IONIC CURRENT SYSTEMS | - |
dc.subject | SARCOPLASMIC-RETICULUM | - |
dc.subject | MATHEMATICAL-MODEL | - |
dc.subject | ELECTRICAL-ACTIVITY | - |
dc.subject | RYANODINE RECEPTOR | - |
dc.subject | SIGNALING PATHWAY | - |
dc.title | Cardiac Systems Biology and Parameter Sensitivity Analysis: Intracellular Ca2+ Regulatory Mechanisms in Mouse Ventricular Myocytes | - |
dc.type | Article | - |
dc.identifier.wosid | 000260375400002 | - |
dc.identifier.scopusid | 2-s2.0-51049084169 | - |
dc.type.rims | ART | - |
dc.citation.volume | 110 | - |
dc.citation.beginningpage | 25 | - |
dc.citation.endingpage | 45 | - |
dc.citation.publicationname | PROTEIN - PROTEIN INTERACTION BOOK SERIES: ADVANCES IN BIOCHEMICAL ENGINEERING-BIOTECHNOLOGY | - |
dc.identifier.doi | 10.1007/10_2007_093 | - |
dc.contributor.localauthor | Cho, Kwang-Hyun | - |
dc.contributor.nonIdAuthor | Shin, Sung-Young | - |
dc.contributor.nonIdAuthor | Choo, Sang-Mok | - |
dc.contributor.nonIdAuthor | Woo, Sun-Hee | - |
dc.type.journalArticle | Article; Book Chapter | - |
dc.subject.keywordAuthor | Ca2+ regulatory mechanism | - |
dc.subject.keywordAuthor | Computer simulations | - |
dc.subject.keywordAuthor | Functional analysis | - |
dc.subject.keywordAuthor | Intracellular Ca2+ dynamics | - |
dc.subject.keywordAuthor | Mathematical modeling | - |
dc.subject.keywordAuthor | Mouse ventricular myocytes | - |
dc.subject.keywordPlus | SODIUM-CALCIUM EXCHANGE | - |
dc.subject.keywordPlus | RABBIT SINOATRIAL NODE | - |
dc.subject.keywordPlus | CARDIOMYOPATHIC SYRIAN-HAMSTER | - |
dc.subject.keywordPlus | INDUCED HEART-FAILURE | - |
dc.subject.keywordPlus | IONIC CURRENT SYSTEMS | - |
dc.subject.keywordPlus | SARCOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | MATHEMATICAL-MODEL | - |
dc.subject.keywordPlus | ELECTRICAL-ACTIVITY | - |
dc.subject.keywordPlus | RYANODINE RECEPTOR | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
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