DC Field | Value | Language |
---|---|---|
dc.contributor.author | Na, D | ko |
dc.contributor.author | Lee, Doheon | ko |
dc.date.accessioned | 2013-03-08T02:27:35Z | - |
dc.date.available | 2013-03-08T02:27:35Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | ARTIFICIAL IMMUNE SYSTEMS, PROCEEDINGS BOOK SERIES: LECTURE NOTES IN COMPUTER SCIENCE, v.3627, pp.182 - 192 | - |
dc.identifier.issn | 0302-9743 | - |
dc.identifier.uri | http://hdl.handle.net/10203/91839 | - |
dc.description.abstract | Administered antibodies can suppress humoral immune response. Though there are two hypotheses explaining the suppression, such as the epitope-masking and Fc-receptor mediated suppression, the epitope-masking hypothesis has garnered more supports. To better understand how the immune suppression works and to gain a quantitative and qualitative insight, we developed the first mathematical immune suppression model based on the epitope-masking hypothesis. However, because the hypothesis does not account for the actual B suppression mechanism, the fact that antigen-depletion induces the arrest of proliferating B cells was incorporated to the model. The model can reproduce immune suppression phenomena and complement the epitope-masking hypothesis by suggesting that the key mechanism for the suppression is the arrest of proliferating B cells and it was shown to be feasible. It is expected that our model gives a new insight to researchers in designing experiments for discovering the underlying mechanism of immune suppression. | - |
dc.language | English | - |
dc.publisher | SPRINGER-VERLAG BERLIN | - |
dc.subject | IGG-MEDIATED SUPPRESSION | - |
dc.subject | FC-GAMMA-RIIB | - |
dc.subject | PRIMARY ANTIBODY-RESPONSES | - |
dc.subject | T-CELL RESPONSE | - |
dc.subject | IN-VIVO | - |
dc.subject | B-CELLS | - |
dc.subject | VIRUS | - |
dc.subject | INFECTION | - |
dc.subject | SURVIVAL | - |
dc.subject | ERYTHROCYTES | - |
dc.title | Mathematical modeling of immune suppression | - |
dc.type | Article | - |
dc.identifier.wosid | 000231416700014 | - |
dc.identifier.scopusid | 2-s2.0-26944496403 | - |
dc.type.rims | ART | - |
dc.citation.volume | 3627 | - |
dc.citation.beginningpage | 182 | - |
dc.citation.endingpage | 192 | - |
dc.citation.publicationname | ARTIFICIAL IMMUNE SYSTEMS, PROCEEDINGS BOOK SERIES: LECTURE NOTES IN COMPUTER SCIENCE | - |
dc.contributor.localauthor | Lee, Doheon | - |
dc.contributor.nonIdAuthor | Na, D | - |
dc.type.journalArticle | Article; Proceedings Paper | - |
dc.subject.keywordPlus | IGG-MEDIATED SUPPRESSION | - |
dc.subject.keywordPlus | FC-GAMMA-RIIB | - |
dc.subject.keywordPlus | PRIMARY ANTIBODY-RESPONSES | - |
dc.subject.keywordPlus | T-CELL RESPONSE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | ERYTHROCYTES | - |
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