Investigation of multicomponent diffusion in cat brain using a combined MTC-DWI approach

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In this study, multiple-component water diffusion in the cat brain is investigated using an approach that combines diffusion-weighted images using multiple b values with magnetization transfer contrast (MTC). The MTC allows filter of signal originating from water molecules that rapidly exchange with binding sites on large macromolecular structures, and in brain white matter, it is assumed that a significant portion of the MTC is due to the interaction of water with the extraaxonal myelin sheath. Henceforth, multicomponent analysis of diffusion curves with and without MTC may shed light on the contribution of the extraaxonal water to the diffusion signal and on the relationship between diffusion components and tissue compartments in the brain. When a biexponential model was applied to the data, the volume fractions of the two diffusion components changed significantly in white matter with the application of the MTC. These changes are then discussed in the frame of tissue components and the possible interaction with the myelin sheath. (c) 2006 Elsevier Inc. All rights reserved.
Publisher
ELSEVIER SCIENCE INC
Issue Date
2006-05
Language
English
Article Type
Article; Proceedings Paper
Keywords

BOVINE OPTIC-NERVE; ISCHEMIC RAT-BRAIN; MAGNETIZATION-TRANSFER; APPARENT DIFFUSION; WATER DIFFUSION; WHITE-MATTER; WEIGHTED MRI; SPINAL-CORD; NMR; SPACE

Citation

MAGNETIC RESONANCE IMAGING, v.24, pp.425 - 431

ISSN
0730-725X
DOI
10.1016/j.mri.2005.12.022
URI
http://hdl.handle.net/10203/90924
Appears in Collection
EE-Journal Papers(저널논문)
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