Dissimilar kinetic behavior of electrically manipulated single- and double-stranded DNA tethered to a gold surface

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We report on the electrical manipulation of single- and double-stranded oligodeoxynucleotides that are end tethered to gold surfaces in electrolyte solution. The response to alternating repulsive and attractive electric surface fields is studied by time-resolved fluorescence measurements, revealing markedly distinct dynamics for the flexible single-stranded and stiff double-stranded DNA, respectively. Hydrodynamic simulations rationalize this finding and disclose two different kinetic mechanisms: stiff polymers undergo rotation around the anchoring pivot point; flexible polymers, on the other hand, are pulled onto the attracting surface segment by segment.
Publisher
BIOPHYSICAL SOCIETY
Issue Date
2006-05
Language
English
Article Type
Article
Keywords

MONOLAYERS; MOLECULES

Citation

BIOPHYSICAL JOURNAL, v.90, no.10, pp.3666 - 3671

ISSN
0006-3495
DOI
10.1529/biophysj.105.078857
URI
http://hdl.handle.net/10203/90780
Appears in Collection
NT-Journal Papers(저널논문)
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