DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim M.S. | ko |
dc.contributor.author | Park, Je-Kyun | ko |
dc.date.accessioned | 2013-03-07T16:45:14Z | - |
dc.date.available | 2013-03-07T16:45:14Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-12 | - |
dc.identifier.citation | JOURNAL OF THE ASSOCIATION FOR LABORATORY AUTOMATION, v.11, no.6, pp.352 - 359 | - |
dc.identifier.issn | 1535-5535 | - |
dc.identifier.uri | http://hdl.handle.net/10203/90715 | - |
dc.description.abstract | This article describes a novel microfluidic 3-dimensional encapsulation method via the self-assembling peptide hydrogel. The microfluidic immobilization strategies using a peptide hydrogel have been designed for microfluidic cell-based assays, cocultures, and biomimetic micro blood vessels. A sol-gel transition peptide hydrogel, Puramatrix, is adopted for use in the microfluidic device fabricated by photolithography and a poly(dimethylsiloxane) replica molding process. The peptide hydrogel was hydrodynamically focused by sheath flows of distilled water and cell culture media, and gelled by diffusion of media. After being transitioned from a sol to gel phase, the fabricated scaffold in the middle of the main channel was not washed away via fluid flows. The diffused chemicals in a stripe-shaped peptide scaffold of microchannel formed a linear concentration gradient within the scaffold. Based on application in an in vivo-like 3-dimensional microenvironment, this microfluidic system could be applied to cocultures, angiological research, cytotoxicity tests, cell viability monitoring, and continuous dose-response assays as well as drug-drug interaction studies. ? 2006 The Association for Laboratory Automation. | - |
dc.language | English | - |
dc.publisher | Association for Laboratory Automation | - |
dc.title | Microfluidic 3-Dimensional Encapsulation System by Self-Assembling Peptide Hydrogel | - |
dc.type | Article | - |
dc.identifier.scopusid | 2-s2.0-33845407168 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 352 | - |
dc.citation.endingpage | 359 | - |
dc.citation.publicationname | JOURNAL OF THE ASSOCIATION FOR LABORATORY AUTOMATION | - |
dc.identifier.doi | 10.1016/j.jala.2006.08.010 | - |
dc.contributor.localauthor | Park, Je-Kyun | - |
dc.contributor.nonIdAuthor | Kim M.S. | - |
dc.subject.keywordAuthor | 3-dimensional | - |
dc.subject.keywordAuthor | biomimetic micro | - |
dc.subject.keywordAuthor | blood vessel | - |
dc.subject.keywordAuthor | cell-based assays | - |
dc.subject.keywordAuthor | coculture | - |
dc.subject.keywordAuthor | encapsulation | - |
dc.subject.keywordAuthor | gradient | - |
dc.subject.keywordAuthor | linear concentration | - |
dc.subject.keywordAuthor | microfluidic | - |
dc.subject.keywordAuthor | microfluidics | - |
dc.subject.keywordAuthor | peptide hydrogel | - |
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