DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Min-chul | ko |
dc.contributor.author | Koo, Bon-Kyoung | ko |
dc.contributor.author | Moon, Jin-Sook | ko |
dc.contributor.author | Kim, Yoon-Young | ko |
dc.contributor.author | Park, Ki Cheol | ko |
dc.contributor.author | Kim, Nam-Shik | ko |
dc.contributor.author | Kwon, Mi Yi | ko |
dc.contributor.author | Kong, Myung-Phil | ko |
dc.contributor.author | Yoon, Ki-Jun | ko |
dc.contributor.author | Im, Sun-Kyoung | ko |
dc.contributor.author | Ghim, Jaewang | ko |
dc.contributor.author | Han, Yong Mahn | ko |
dc.contributor.author | Jang, Sung Key | ko |
dc.contributor.author | Shong, Minho | ko |
dc.contributor.author | Kong, Young-Yun | ko |
dc.date.accessioned | 2013-03-07T14:20:03Z | - |
dc.date.available | 2013-03-07T14:20:03Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-02 | - |
dc.identifier.citation | EMBO JOURNAL, v.27, no.4, pp.642 - 653 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | http://hdl.handle.net/10203/90390 | - |
dc.description.abstract | Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor that performs a broad spectrum of biological functions in response to various stimuli. However, no specific coactivator that regulates the transcriptional activity of STAT3 has been identified. Here we report that CR6-interacting factor 1 (Crif1) is a specific transcriptional coactivator of STAT3, but not of STAT1 or STAT5a. Crif1 interacts with STAT3 and positively regulates its transcriptional activity. Crif1(-/-) embryos were lethal around embryonic day 6.5, and manifested developmental arrest accompanied with defective proliferation and massive apoptosis. The expression of STAT3 target genes was markedly reduced in a Crif1(-/-) blastocyst culture and in Oncostatin M-stimulated Crif1-deficient MEFs. Importantly, the key activities of constitutively active STAT3-C, such as transcription, DNA binding, and cellular transformation, were abolished in the Crif1-null MEFs, suggesting the essential role of Crif1 in the transcriptional activity of STAT3. Our results reveal that Crif1 is a novel and essential transcriptional coactivator of STAT3 that modulates its DNA binding ability, and shed light on the regulation of oncogenic STAT3. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Crif1 is a novel transcriptional coactivator of STAT3 | - |
dc.type | Article | - |
dc.identifier.wosid | 000253409300006 | - |
dc.identifier.scopusid | 2-s2.0-39449123058 | - |
dc.type.rims | ART | - |
dc.citation.volume | 27 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 642 | - |
dc.citation.endingpage | 653 | - |
dc.citation.publicationname | EMBO JOURNAL | - |
dc.identifier.doi | 10.1038/sj.emboj.7601986 | - |
dc.contributor.localauthor | Yoon, Ki-Jun | - |
dc.contributor.localauthor | Han, Yong Mahn | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Kwon, Min-chul | - |
dc.contributor.nonIdAuthor | Koo, Bon-Kyoung | - |
dc.contributor.nonIdAuthor | Moon, Jin-Sook | - |
dc.contributor.nonIdAuthor | Kim, Yoon-Young | - |
dc.contributor.nonIdAuthor | Park, Ki Cheol | - |
dc.contributor.nonIdAuthor | Kim, Nam-Shik | - |
dc.contributor.nonIdAuthor | Kwon, Mi Yi | - |
dc.contributor.nonIdAuthor | Kong, Myung-Phil | - |
dc.contributor.nonIdAuthor | Im, Sun-Kyoung | - |
dc.contributor.nonIdAuthor | Ghim, Jaewang | - |
dc.contributor.nonIdAuthor | Jang, Sung Key | - |
dc.contributor.nonIdAuthor | Kong, Young-Yun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Crif1 | - |
dc.subject.keywordAuthor | embryogenesis | - |
dc.subject.keywordAuthor | STAT3 | - |
dc.subject.keywordAuthor | transcriptional coactivator | - |
dc.subject.keywordAuthor | tumorigenesis | - |
dc.subject.keywordPlus | CR6-INTERACTING FACTOR-1 INTERACTS | - |
dc.subject.keywordPlus | COILED-COIL DOMAIN | - |
dc.subject.keywordPlus | FUNCTIONAL INTERACTION | - |
dc.subject.keywordPlus | TARGETED DISRUPTION | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | MICE LACKING | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | GENE | - |
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