Poly(ADP-ribosyl)ation by PARP-1: PAR-laying NAD+ into a nuclear signal

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Poly(ADP-ribose) (PAR) and the PAR polymerases (PARPs) that catalyze its synthesis from donor nicotinamide adenine dinucleotide (NAD(+)) molecules have received considerable attention in the recent literature. Poly(ADP-ribosyl)ation (PARylation) plays diverse roles in many molecular and cellular processes, including DNA damage detection and repair, chromatin modification, transcription, cell death pathways, insulator function, and mitotic apparatus function. These processes are critical for many physiological and pathophysiological outcomes, including genome maintenance, carcinogenesis, aging, inflammation, and neuronal function. This review highlights recent work on the biochemistry, molecular biology, physiology, and pathophysiology of PARylation, focusing on the activity of PARP-1, the most abundantly expressed member of a family of PARP proteins. In addition, connections between nuclear NAD' metabolism and nuclear signaling through PARP-1 are discussed.
Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Issue Date
2005-09
Language
English
Article Type
Review
Keywords

APOPTOSIS-INDUCING FACTOR; WERNER-SYNDROME PROTEIN; ADP-RIBOSE SYNTHETASE; NF-KAPPA-B; DNA-DAMAGE; CELL-DEATH; CHROMATIN-STRUCTURE; POLYMERASE-ACTIVITY; GENOMIC STABILITY; MAMMALIAN-CELLS

Citation

GENES & DEVELOPMENT, v.19, no.17, pp.1951 - 1967

ISSN
0890-9369
DOI
10.1101/gad.1331805
URI
http://hdl.handle.net/10203/90306
Appears in Collection
BS-Journal Papers(저널논문)
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