DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sik | ko |
dc.contributor.author | Kim, Won | ko |
dc.contributor.author | Moon, Sang-Ok | ko |
dc.contributor.author | Sung, Mi Jeong | ko |
dc.contributor.author | Kim, Duk Hoon | ko |
dc.contributor.author | Kang, Kyung Pyo | ko |
dc.contributor.author | Jang, Kyu Yoon | ko |
dc.contributor.author | Lee, Sang Yong | ko |
dc.contributor.author | Park, Byung-Hyun | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Park, Sung Kwang | ko |
dc.date.accessioned | 2013-03-07T12:27:51Z | - |
dc.date.available | 2013-03-07T12:27:51Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-02 | - |
dc.identifier.citation | NEPHROLOGY DIALYSIS TRANSPLANTATION, v.22, no.2, pp.396 - 408 | - |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.uri | http://hdl.handle.net/10203/90180 | - |
dc.description.abstract | Background. Inflammatory processes have been recently seen as underlying the pathogenesis of diabetic nephropathy. Angiopoietin-1 (Ang1) plays essential roles in regulating vascular growth, development, maturation, permeability and inflammation. We have developed a soluble, stable and potent Ang1 variant, cartilage oligomeric matrix protein (COMP)-Ang1. Methods. In this study, db/db mice were treated with recombinant adenovirus expressing either COMP-Ang1 or LacZ. Histology, inflammatory, metabolic, and fibrotic parameters and signalling pathway were evaluated. Results. COMP-Ang1 reduced albuminuria and decreased mesangial expansion, thickening of the glomerular basement membrane and podocyte foot process broadening and effacement. COMP-Ang1 suppressed both renal expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 and monocyte/macrophage infiltration in diabetic db/db mice. COMP-Ang1 also reduced renal tissue levels of transforming growth factor-beta 1 (TGF-beta 1), alpha-smooth muscle actin, fibronectin, as well as Smad 2/3 expression, but increased Smad 7 expression. In human umbilical vein endothelial cells (HUVECs) grown in high glucose concentrations of glucose, recombinant COMP-Ang1 protein decreased nuclear factor-kappa B (NF-kappa B) expression. COMP-Ang1-mediated inhibition of increased NF-kappa B-DNA binding in nuclear extracts from HUVECs grown in high glucose was significantly blocked by soluble Tie2 receptor-Fc. In addition, COMP-Ang1 significantly decreased fasting blood glucose level, epididymal fat weight to body weight ratio, and epididymal adipocyte size in diabetic db/db mice. After intraperitoneal glucose challenge, COMP-Ang1 significantly lowered plasma glucose levels. However, there was no difference in serum insulin levels. Conclusion. We conclude that COMP-Ang1 delayed the fibrotic changes in the kidney of diabetic db/db mice through its anti-inflammatory or metabolic effects. | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes | - |
dc.type | Article | - |
dc.identifier.wosid | 000243805400017 | - |
dc.identifier.scopusid | 2-s2.0-33846677486 | - |
dc.type.rims | ART | - |
dc.citation.volume | 22 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 396 | - |
dc.citation.endingpage | 408 | - |
dc.citation.publicationname | NEPHROLOGY DIALYSIS TRANSPLANTATION | - |
dc.identifier.doi | 10.1093/ndt/gfl598 | - |
dc.contributor.localauthor | Park, Byung-Hyun | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Lee, Sik | - |
dc.contributor.nonIdAuthor | Kim, Won | - |
dc.contributor.nonIdAuthor | Moon, Sang-Ok | - |
dc.contributor.nonIdAuthor | Sung, Mi Jeong | - |
dc.contributor.nonIdAuthor | Kim, Duk Hoon | - |
dc.contributor.nonIdAuthor | Kang, Kyung Pyo | - |
dc.contributor.nonIdAuthor | Jang, Kyu Yoon | - |
dc.contributor.nonIdAuthor | Lee, Sang Yong | - |
dc.contributor.nonIdAuthor | Park, Sung Kwang | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | COMP-angiopoietin-1 | - |
dc.subject.keywordAuthor | diabetic db/db mouse | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | kidney | - |
dc.subject.keywordPlus | DESIGNED ANGIOPOIETIN-1 VARIANT | - |
dc.subject.keywordPlus | RENAL INJURY | - |
dc.subject.keywordPlus | NEPHROPATHY | - |
dc.subject.keywordPlus | COMP-ANG1 | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | INHIBITOR | - |
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