DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤세찬 | ko |
dc.contributor.author | 이동우 | ko |
dc.contributor.author | 조영호 | ko |
dc.date.accessioned | 2013-03-07T06:15:21Z | - |
dc.date.available | 2013-03-07T06:15:21Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-10 | - |
dc.identifier.citation | 대한기계학회논문집 A, v.32, no.10, pp.844 - 849 | - |
dc.identifier.issn | 1226-4873 | - |
dc.identifier.uri | http://hdl.handle.net/10203/89573 | - |
dc.description.abstract | We present a novel cell deformability monitoring chip based on the digitally measured cell lysis rate which is dependent on the areal strain of the cell membrane. This method offers simple cell deformability monitoring by automated high-throughput testing system. We suggest the filter design considering the areal strain imposed on the cell membrane passing through the filter array having gradually increased orifice length. In the experiment using erythrocytes, we characterized the cell deformability in terms of average fracture areal strain which was 0.24±0.014 and 0.21±0.002 for normal and chemically treated erythrocytes, respectively. We also verified that the areal strain of 0.15 effectively discriminates the deformability difference of normal and chemically treated erythrocytes, which can be applied to the clinical situation. We compared the lysis rates and their difference for the samples from different donors and found that the present chips can be commonly used without any calibration process. The experimental results demonstrate the simple structure and high performance of the present cell deformability monitoring chips, applicable to simple and cost-effective cell aging process monitoring | - |
dc.language | Korean | - |
dc.publisher | 대한기계학회 | - |
dc.title | 미소유로의 길이에 따른 통과세포의 파괴율을 바탕으로 한 생체모사 세포 변형성 검사칩에 관한 연구 | - |
dc.title.alternative | Bio-inspired Cell Deformability Monitoring Chips Based on Strain Dependent Digital Lysis Rates | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.citation.volume | 32 | - |
dc.citation.issue | 10 | - |
dc.citation.beginningpage | 844 | - |
dc.citation.endingpage | 849 | - |
dc.citation.publicationname | 대한기계학회논문집 A | - |
dc.identifier.kciid | ART001280653 | - |
dc.contributor.localauthor | 조영호 | - |
dc.contributor.nonIdAuthor | 윤세찬 | - |
dc.contributor.nonIdAuthor | 이동우 | - |
dc.subject.keywordAuthor | 세포 변형성 | - |
dc.subject.keywordAuthor | 적혈구 변형성 | - |
dc.subject.keywordAuthor | 세포 파괴 | - |
dc.subject.keywordAuthor | 적혈구 | - |
dc.subject.keywordAuthor | Cell Deformability | - |
dc.subject.keywordAuthor | Erythrocyte Deformability | - |
dc.subject.keywordAuthor | Cell Lysis | - |
dc.subject.keywordAuthor | Red Blood Cell | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.