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College of Engineering(공과대학)Dept. of Bio and Brain Engineering(바이오및뇌공학과)BiS-Journal Papers(저널논문)

Nanoparticle self-assembly directed by antagonistic kinase and phosphatase activities

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dc.contributor.authorvon Maltzahn, Geoffreyko
dc.contributor.authorMin, Dal-Heeko
dc.contributor.authorZhang, Yingxinko
dc.contributor.authorPark, Ji-Hoko
dc.contributor.authorHarris, Todd J.ko
dc.contributor.authorSailor, Michaelko
dc.contributor.authorBhatia, Sangeeta N.ko
dc.date.accessioned2013-03-07T05:17:59Z-
dc.date.available2013-03-07T05:17:59Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2007-11-
dc.identifier.citationADVANCED MATERIALS, v.19, no.21, pp.3579 - 3579-
dc.identifier.issn0935-9648-
dc.identifier.urihttp://hdl.handle.net/10203/89471-
dc.description.abstractSuperparamagnetic Fe3O4 nanoparticles (NPs) are engineered to reversibly self-assemble in response to antagonistic enzyme inputs. Tyrosine kinase activity directs substrate-NPs and SH2 domain-NPs to coalesce via polyvalent SH2- phosphopeptide binding. Phosphatase antagonizes this process and directs NP dispersion. By coupling assembly to substrate phosphorylation, the kinase activity is imaged via quantitative T2 relaxation changes in MRI.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectTYROSINE KINASE-
dc.subjectMOLECULAR-INTERACTIONS-
dc.subjectSIGNAL-TRANSDUCTION-
dc.subjectGOLD NANOPARTICLES-
dc.subjectQUANTUM DOTS-
dc.subjectPHOSPHORYLATION-
dc.subjectMULTIVALENT-
dc.subjectNANOSENSORS-
dc.subjectRECEPTORS-
dc.subjectDELIVERY-
dc.titleNanoparticle self-assembly directed by antagonistic kinase and phosphatase activities-
dc.typeArticle-
dc.identifier.wosid000250992000027-
dc.identifier.scopusid2-s2.0-36248934698-
dc.type.rimsART-
dc.citation.volume19-
dc.citation.issue21-
dc.citation.beginningpage3579-
dc.citation.endingpage3579-
dc.citation.publicationnameADVANCED MATERIALS-
dc.identifier.doi10.1002/adma.200701183-
dc.contributor.localauthorMin, Dal-Hee-
dc.contributor.localauthorPark, Ji-Ho-
dc.contributor.nonIdAuthorvon Maltzahn, Geoffrey-
dc.contributor.nonIdAuthorZhang, Yingxin-
dc.contributor.nonIdAuthorHarris, Todd J.-
dc.contributor.nonIdAuthorSailor, Michael-
dc.contributor.nonIdAuthorBhatia, Sangeeta N.-
dc.type.journalArticleArticle-
dc.subject.keywordPlusTYROSINE KINASE-
dc.subject.keywordPlusMOLECULAR-INTERACTIONS-
dc.subject.keywordPlusSIGNAL-TRANSDUCTION-
dc.subject.keywordPlusGOLD NANOPARTICLES-
dc.subject.keywordPlusQUANTUM DOTS-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordPlusMULTIVALENT-
dc.subject.keywordPlusNANOSENSORS-
dc.subject.keywordPlusRECEPTORS-
dc.subject.keywordPlusDELIVERY-
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CH-Journal Papers(저널논문)BiS-Journal Papers(저널논문)
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