DC Field | Value | Language |
---|---|---|
dc.contributor.author | Inoue, T | ko |
dc.contributor.author | Heo, Won Do | ko |
dc.contributor.author | Grimley, JS | ko |
dc.contributor.author | Wandless, TJ | ko |
dc.contributor.author | Meyer, T | ko |
dc.date.accessioned | 2013-03-07T01:49:06Z | - |
dc.date.available | 2013-03-07T01:49:06Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2005-06 | - |
dc.identifier.citation | NATURE METHODS, v.2, no.6, pp.415 - 418 | - |
dc.identifier.issn | 1548-7091 | - |
dc.identifier.uri | http://hdl.handle.net/10203/89142 | - |
dc.description.abstract | We made substantial advances in the implementation of a rapa mycin-triggered heterodimerization strategy. Using molecular engineering of different targeting and enzymatic fusion constructs and a new rapamycin analog, Rho GTPases were directly activated or inactivated on a timescale of seconds, which was followed by pronounced cell morphological changes. As signaling processes often occur within minutes, such rapid perturbations provide a powerful tool to investigate the role, selectivity and timing of Rho GTPase-mediated signaling processes. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways | - |
dc.type | Article | - |
dc.identifier.wosid | 000229424300011 | - |
dc.identifier.scopusid | 2-s2.0-21444442055 | - |
dc.type.rims | ART | - |
dc.citation.volume | 2 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 415 | - |
dc.citation.endingpage | 418 | - |
dc.citation.publicationname | NATURE METHODS | - |
dc.identifier.doi | 10.1038/NMETH763 | - |
dc.contributor.localauthor | Heo, Won Do | - |
dc.contributor.nonIdAuthor | Inoue, T | - |
dc.contributor.nonIdAuthor | Grimley, JS | - |
dc.contributor.nonIdAuthor | Wandless, TJ | - |
dc.contributor.nonIdAuthor | Meyer, T | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ACTIN POLYMERIZATION | - |
dc.subject.keywordPlus | MEMBRANE RECRUITMENT | - |
dc.subject.keywordPlus | BINDING PROTEINS | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | RAC | - |
dc.subject.keywordPlus | DOMAIN | - |
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