DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Daejong | ko |
dc.contributor.author | Chu, K | ko |
dc.contributor.author | Jung, KH | ko |
dc.contributor.author | Kim, M | ko |
dc.contributor.author | Yoon, BW | ko |
dc.contributor.author | Lee, CJ | ko |
dc.contributor.author | Oh, U | ko |
dc.contributor.author | Shin, HS | ko |
dc.date.accessioned | 2013-03-07T01:06:36Z | - |
dc.date.available | 2013-03-07T01:06:36Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-05 | - |
dc.identifier.citation | CELL CALCIUM, v.43, pp.482 - 491 | - |
dc.identifier.issn | 0143-4160 | - |
dc.identifier.uri | http://hdl.handle.net/10203/89028 | - |
dc.description.abstract | Na(+)/Ca(2+) exchanger (NCX), by mediating Na(+) and Ca(2+), fluxes bi-directionally, assumes a role in controlling the Ca(2+) homeostasis in the ischemic brain. It has been suggested that the three isoforms of NCX (NCX1, 2 and 3) may be differentially involved in permanent cerebral ischemia. However, the role of NCX2 has not been defined in ischemic reperfusion injury after a transient focal cerebral ischemia. Furthermore, it is not known whether NCX2 imports or exports intracellular Ca(2+)([Ca(2+)](i)) following ischemia and reperfusion. To define the role of NCX2 in ischemia and reperfusion, we examined mice lacking NCX2, in vivo and in vitro. After an in vitro ischemia, a significantly slower recovery in population spike amplitudes, a sustained elevation of [Ca(2+)](i) and an increased membrane depolarization were developed in the NCX2-deficient hippocampus. Moreover, a transient focal cerebral ischemia in vivo produced a larger infarction and more cell death in the NCX2-deficient mouse brain. In particular, in the wild type brain, NCX2-expressing neurons were largely spared from cell death after ischemia. Our results suggest that NCX2 exports Ca(2+) in ischemia and thus protects neuronal cells from death by reducing [Ca(2+)](i) in the adult mouse brain. (c) 2007 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | CHURCHILL LIVINGSTONE | - |
dc.subject | SODIUM-CALCIUM EXCHANGE | - |
dc.subject | NA+-CA2+ EXCHANGER | - |
dc.subject | BRAIN-REGIONS | - |
dc.subject | RAT-BRAIN | - |
dc.subject | IN-VITRO | - |
dc.subject | EXPRESSION | - |
dc.subject | NCX3 | - |
dc.subject | ISOFORMS | - |
dc.subject | NEURONS | - |
dc.subject | CLONING | - |
dc.title | Na+/Ca2+ exchanger 2 is neuroprotective by exporting Ca2+ during a transient focal cerebral ischemia in the mouse | - |
dc.type | Article | - |
dc.identifier.wosid | 000256325900006 | - |
dc.identifier.scopusid | 2-s2.0-42149087628 | - |
dc.type.rims | ART | - |
dc.citation.volume | 43 | - |
dc.citation.beginningpage | 482 | - |
dc.citation.endingpage | 491 | - |
dc.citation.publicationname | CELL CALCIUM | - |
dc.identifier.doi | 10.1016/j.ceca.2007.08.003 | - |
dc.contributor.localauthor | Jeon, Daejong | - |
dc.contributor.nonIdAuthor | Chu, K | - |
dc.contributor.nonIdAuthor | Jung, KH | - |
dc.contributor.nonIdAuthor | Kim, M | - |
dc.contributor.nonIdAuthor | Yoon, BW | - |
dc.contributor.nonIdAuthor | Lee, CJ | - |
dc.contributor.nonIdAuthor | Oh, U | - |
dc.contributor.nonIdAuthor | Shin, HS | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cerebral ischemia | - |
dc.subject.keywordAuthor | Na(+)/Ca(2+) exchanger | - |
dc.subject.keywordAuthor | NCX2-deficient mice | - |
dc.subject.keywordAuthor | [Ca(2+)](i) | - |
dc.subject.keywordAuthor | population spike | - |
dc.subject.keywordAuthor | membrane depolarization | - |
dc.subject.keywordPlus | SODIUM-CALCIUM EXCHANGE | - |
dc.subject.keywordPlus | NA+-CA2+ EXCHANGER | - |
dc.subject.keywordPlus | BRAIN-REGIONS | - |
dc.subject.keywordPlus | RAT-BRAIN | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | NCX3 | - |
dc.subject.keywordPlus | ISOFORMS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | CLONING | - |
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