An 11-year-old male South American sea lion (Otaria Byronia) found dead in the near commercial aquarium. Animal had been shown chronic diarrhea, and had one-week history of anorexia. At necropsy, lung revealed severe hyperemia, hemorrhage diffusely and discolorization. Stomach and small intestine had hyperemia and mild hemorrhage grossly. Histopathological findings were significant hyperemia and fibrinous bronchopneumonia of lung, chronic catarrhal enteritis, and hyperplasia of lymphoid tissue. Morphological diagnosis was determinated as a fibrinous bronchopneumonia due to secondary infectious disease in asthenia state. Moreover, immune deficiency may be caused by chronic diarrhea, malnutrition, and environmental stress. In this study, necropsy case of sea lion was few occurred in our country. Therefore, our report may be useful for diagnosis clinically and interested veterinary practician.