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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

RhoB is epigenetically regulated in an age- and tissue-specific manner

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dc.contributor.authorYoon, Young Sooko
dc.contributor.authorChoo, Jung Hako
dc.contributor.authorYoo, Taekyungko
dc.contributor.authorKang, Keunsooko
dc.contributor.authorChung, Jae Hoonko
dc.date.accessioned2013-03-06T21:45:25Z-
dc.date.available2013-03-06T21:45:25Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2007-10-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.362, no.1, pp.164 - 169-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10203/88570-
dc.description.abstractRhoB, a member of the Rho family of small GTPases, regulates the organization of the actin cytoskeleton, malignant transformation, and genotoxic stress-induced signaling. In order to characterize epigenetic regulation of RhoB transcription during aging, the mRNA levels of RhoB were investigated using various mouse tissues of different ages. Bisulfite sequencing revealed that the CpG dinucleotide methylation patterns of the RhoB promoter region were not altered in skeletal muscle and lung during aging. ChIP analysis showed that levels of histone H3 and H4 acetylation were reduced in a tissue-specific manner during aging due to direct HDAC I binding. Histone H3 lysine 9 trimethylation level and deposition of HP 10 increased in RhoB promoter during aging, whereas historic H3 lysine 4 dimethylation level gradually decreased. It was concluded that mouse RhoB transcription is epigenetically regulated in a tissue-specific manner during aging by histone modification, but not by CpG methylation. (C) 2007 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectDNA METHYLATION-
dc.subjectGTPASE RHOB-
dc.subjectHISTONE H3-
dc.subjectLYSINE 9-
dc.subjectEXPRESSION-
dc.subjectGENE-
dc.subjectTRANSFORMATION-
dc.subjectCELL-
dc.titleRhoB is epigenetically regulated in an age- and tissue-specific manner-
dc.typeArticle-
dc.identifier.wosid000249357700027-
dc.identifier.scopusid2-s2.0-34548182080-
dc.type.rimsART-
dc.citation.volume362-
dc.citation.issue1-
dc.citation.beginningpage164-
dc.citation.endingpage169-
dc.citation.publicationnameBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.identifier.doi10.1016/j.bbrc.2007.08.002-
dc.contributor.localauthorChung, Jae Hoon-
dc.contributor.nonIdAuthorYoon, Young Soo-
dc.contributor.nonIdAuthorChoo, Jung Ha-
dc.contributor.nonIdAuthorYoo, Taekyung-
dc.contributor.nonIdAuthorKang, Keunsoo-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorRhoB-
dc.subject.keywordAuthoraging-
dc.subject.keywordAuthorDNA methylation-
dc.subject.keywordAuthorhistone modification-
dc.subject.keywordPlusDNA METHYLATION-
dc.subject.keywordPlusGTPASE RHOB-
dc.subject.keywordPlusHISTONE H3-
dc.subject.keywordPlusLYSINE 9-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusTRANSFORMATION-
dc.subject.keywordPlusCELL-
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