DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Ju Hyun | ko |
dc.contributor.author | Sung, Bong Hyun | ko |
dc.contributor.author | Kim, Sun-Chang | ko |
dc.date.accessioned | 2009-04-13T06:44:39Z | - |
dc.date.available | 2009-04-13T06:44:39Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.citation | BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v.1788, no.8, pp.1564 - 1569 | - |
dc.identifier.issn | 0005-2736 | - |
dc.identifier.uri | http://hdl.handle.net/10203/8740 | - |
dc.description.abstract | Antimicrobial peptides (AMPs) constitute an important component of the innate immune system in a variety of organisms. Buforin I is a 39-amino acid AMP that was first isolated from the stomach tissue of the Asian toad Bufo bufo gargarizans. Buforin 11 is a 21-amino acid peptide that is derived from buforin I and displays an even more potent antimicrobial activity than its parent AMP. Both peptides share complete sequence identity with the N-terminal region of histone H2A that interacts directly with nucleic acids. Buforin I is generated from histone H2A by pepsin-directed proteolysis in the cytoplasm of gastric gland cells. After secretion into the gastric lumen, buforin I remains adhered to the mucous biofilm that lines the stomach, thus providing a protective antimicrobial coat. Buforins, which house a helix-hinge-helix domain, kill a microorganism by entering the cell without membrane permeabilization and thus binding to nucleic acids. The proline hinge is crucial for the cell penetrating activity of buforins. Buforins also are known to possess anti-endotoxin and anticancer activities, thus making these peptides attractive reagents for pharmaceutical applications. This review describes the role of buforins in innate host defense; future research paradigms: and use of these agents as human therapeutics. (C) 2008 Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | This work was supported by grants from the 21C Frontier Program of Microbial Genomics and Applications (MG08-0204-1-0) and the Research Program of New Drug Target Discovery (M10748000314-08N4800-31410) from the Ministry of Education, Science and Technology of Korea, and by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2007-313-C00670). | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | HOST-DEFENSE PEPTIDES | - |
dc.subject | POLYCATIONIC PEPTIDES | - |
dc.subject | CATIONIC PEPTIDES | - |
dc.subject | ESCHERICHIA-COLI | - |
dc.subject | ANTIBACTERIAL PEPTIDE | - |
dc.subject | PARASIN-I | - |
dc.subject | CRYPTOSPORIDIUM-PARVUM | - |
dc.subject | ANTICANCER ACTIVITY | - |
dc.subject | ATLANTIC SALMON | - |
dc.subject | INNATE IMMUNITY | - |
dc.title | Buforins: Histone H2A-derived antimicrobial peptides from toad stomach | - |
dc.type | Article | - |
dc.identifier.wosid | 000267772200005 | - |
dc.identifier.scopusid | 2-s2.0-67649406168 | - |
dc.type.rims | ART | - |
dc.citation.volume | 1788 | - |
dc.citation.issue | 8 | - |
dc.citation.beginningpage | 1564 | - |
dc.citation.endingpage | 1569 | - |
dc.citation.publicationname | BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | - |
dc.identifier.doi | 10.1016/j.bbamem.2008.10.025 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Sun-Chang | - |
dc.contributor.nonIdAuthor | Cho, Ju Hyun | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordAuthor | Antimicrobial peptide | - |
dc.subject.keywordAuthor | Buforin | - |
dc.subject.keywordAuthor | Histone H2A | - |
dc.subject.keywordAuthor | Structure-activity | - |
dc.subject.keywordAuthor | Proline hinge | - |
dc.subject.keywordPlus | HOST-DEFENSE PEPTIDES | - |
dc.subject.keywordPlus | POLYCATIONIC PEPTIDES | - |
dc.subject.keywordPlus | CATIONIC PEPTIDES | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | ANTIBACTERIAL PEPTIDE | - |
dc.subject.keywordPlus | PARASIN-I | - |
dc.subject.keywordPlus | CRYPTOSPORIDIUM-PARVUM | - |
dc.subject.keywordPlus | ANTICANCER ACTIVITY | - |
dc.subject.keywordPlus | ATLANTIC SALMON | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.