Component-based software architecture for biosystem reverse engineering

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Reverse engineering is defined as the process where the internal structures and dynamics of a given system are inferred and analyzed from external observations and relevant knowledge. The first part of this paper surveys existing techniques for biosystem reverse engineering. Network structure inference techniques such as Correlation Matrix Construction (CIVIC), Boolean network and Bayesian network-based methods are explained. After the numeric and logical simulation techniques are briefly described, several representative working software tools were introduced. The second part presents our component-based software architecture for biosystem reverse engineering. After three design principles are established, a loosely coupled federation architecture consisting of 11 autonomous components is proposed along with their respective functions.
Publisher
KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
Issue Date
2005-09
Language
English
Article Type
Review
Keywords

EXPRESSION DATA; INTERACTION NETWORKS; REGULATORY NETWORKS; METABOLIC NETWORK; SYSTEMS BIOLOGY; SIMULATION; MODELS; ENVIRONMENT; REPRESENTATION; CONSTRUCTION

Citation

BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.10, pp.400 - 407

ISSN
1226-8372
DOI
10.1007/BF02989822
URI
http://hdl.handle.net/10203/87039
Appears in Collection
BiS-Journal Papers(저널논문)
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