Induction of homosynaptic long-term depression in entorhinal cortex

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Prolonged low frequency stimulation (1 Hz, 15 min) induced significant long-term depression (LTD) in hippocampal CA1 region and superficial, but not deep, layers of rat medial entorhinal cortex (EC) in vitro. In the presence of D-AP5, significant LTD was induced in EC superficial layers, but not in CA1 or EC deep layers. These results show differences in characteristics of LTD induction across CA1, EC superficial layers, and EC deep layers. (C) 2002 Elsevier Science B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2002-11
Language
English
Article Type
Article
Keywords

CHOLINERGIC MODULATION; AREA CA1; HIPPOCAMPUS; POTENTIATION; RAT; MEMORY

Citation

BRAIN RESEARCH, v.954, no.2, pp.308 - 310

ISSN
0006-8993
DOI
10.1016/S0006-8993(02)03516-3
URI
http://hdl.handle.net/10203/85912
Appears in Collection
BS-Journal Papers(저널논문)
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