DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ho Min | ko |
dc.contributor.author | Yu, KS | ko |
dc.contributor.author | Lee, ME | ko |
dc.contributor.author | Shin, DR | ko |
dc.contributor.author | Kim, YS | ko |
dc.contributor.author | Paik, SG | ko |
dc.contributor.author | Yoo, Ook-Joon | ko |
dc.contributor.author | Lee, H | ko |
dc.contributor.author | Lee, Jie-Oh | ko |
dc.date.accessioned | 2013-03-06T04:34:04Z | - |
dc.date.available | 2013-03-06T04:34:04Z | - |
dc.date.created | 2012-06-18 | - |
dc.date.created | 2012-06-18 | - |
dc.date.issued | 2003-05 | - |
dc.identifier.citation | NATURE STRUCTURAL BIOLOGY, v.10, no.5, pp.342 - 348 | - |
dc.identifier.issn | 1072-8368 | - |
dc.identifier.uri | http://hdl.handle.net/10203/85808 | - |
dc.description.abstract | B-cell activating factor (BAFF) is a key regulator of B-lymphocyte development. Its biological role is mediated by the specific receptors BCMA, TACT and BAFF-R. We have determined the crystal structure of the extracellular domain of BAFF-R bound to BAFF at a resolution of 3.3 Angstrom. The cysteine-rich domain (CRD) of the BAFF-R extracellular domain adopts a beta-hairpin structure and binds to the virus-like BAFF cage in a 1:1 molar ratio. The conserved DxL motif of BAFF-R is located on the tip of the beta-turn and is indispensable in the binding of BAFF. The crystal structure shows that a unique dimeric contact occurs between the BAFF-R monomers in the virus-like cage complex. The extracellular domain of TACI contains two CRDs, both of which contain the DxL motif. Modeling of TACT-BAFF complex suggests that both CDRs simultaneously interact with the BAFF dimer in the virus-like cage. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | NECROSIS-FACTOR RECEPTOR | - |
dc.subject | B-LYMPHOCYTE STIMULATOR | - |
dc.subject | T-CELL ACTIVATION | - |
dc.subject | TNF-RECEPTOR | - |
dc.subject | AUTOIMMUNE-DISEASE | - |
dc.subject | FACTOR FAMILY | - |
dc.subject | MEMBER | - |
dc.subject | TACI | - |
dc.subject | BLYS | - |
dc.subject | MICE | - |
dc.title | Crystal structure of the BAFF-BAFF-R complex and its implications for receptor activation | - |
dc.type | Article | - |
dc.identifier.wosid | 000182536300009 | - |
dc.identifier.scopusid | 2-s2.0-0242684718 | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 342 | - |
dc.citation.endingpage | 348 | - |
dc.citation.publicationname | NATURE STRUCTURAL BIOLOGY | - |
dc.identifier.doi | 10.1038/nsb925 | - |
dc.contributor.localauthor | Kim, Ho Min | - |
dc.contributor.localauthor | Yoo, Ook-Joon | - |
dc.contributor.localauthor | Lee, Jie-Oh | - |
dc.contributor.nonIdAuthor | Yu, KS | - |
dc.contributor.nonIdAuthor | Lee, ME | - |
dc.contributor.nonIdAuthor | Shin, DR | - |
dc.contributor.nonIdAuthor | Kim, YS | - |
dc.contributor.nonIdAuthor | Paik, SG | - |
dc.contributor.nonIdAuthor | Lee, H | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NECROSIS-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | B-LYMPHOCYTE STIMULATOR | - |
dc.subject.keywordPlus | T-CELL ACTIVATION | - |
dc.subject.keywordPlus | TNF-RECEPTOR | - |
dc.subject.keywordPlus | AUTOIMMUNE-DISEASE | - |
dc.subject.keywordPlus | FACTOR FAMILY | - |
dc.subject.keywordPlus | MEMBER | - |
dc.subject.keywordPlus | TACI | - |
dc.subject.keywordPlus | BLYS | - |
dc.subject.keywordPlus | MICE | - |
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