DC Field | Value | Language |
---|---|---|
dc.contributor.author | Borowski, P | ko |
dc.contributor.author | Lang, M | ko |
dc.contributor.author | Niebuhr, A | ko |
dc.contributor.author | Haag, A | ko |
dc.contributor.author | Schmitz, H | ko |
dc.contributor.author | zur Wiesch, JS | ko |
dc.contributor.author | Choe, Joonho | ko |
dc.contributor.author | Siwecka, MA | ko |
dc.contributor.author | Kulikowski, T | ko |
dc.date.accessioned | 2013-03-06T03:44:25Z | - |
dc.date.available | 2013-03-06T03:44:25Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2001-09 | - |
dc.identifier.citation | ACTA BIOCHIMICA POLONICA, v.48, no.3, pp.739 - 744 | - |
dc.identifier.issn | 0001-527X | - |
dc.identifier.uri | http://hdl.handle.net/10203/85716 | - |
dc.description.abstract | In the presented study the ribavirin-TP - an established inhibitor of the NTPase activity of the superfamily NTPase/helicases II - was investigated as an inhibitor of the unwinding activity of the hepatitis C virus (HCV) NTPase/helicase. The kinetics of the reaction revealed that ribavirin-TP reduces the turnover number of the helicase reaction by a mechanism that does not correspond to that of the inhibition of the NTPase activity. Our results suggest that derivatives of ribavirin-TP with enhanced stability towards hydrolytic attack may be effective inhibitors of the enzyme. | - |
dc.language | English | - |
dc.publisher | ACTA BIOCHIMICA POLONICA | - |
dc.subject | HEPATITIS-C VIRUS | - |
dc.subject | RNA HELICASE | - |
dc.subject | NS3 PROTEIN | - |
dc.subject | NUCLEOSIDE 5&apos | - |
dc.subject | -TRIPHOSPHATES | - |
dc.subject | BINDING ACTIVITY | - |
dc.subject | DOMAIN | - |
dc.subject | NTPASE/HELICASE | - |
dc.title | Inhibition of the helicase activity of HCVNTPase/helicase by 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5 -triphosphate (ribavirin-TP) | - |
dc.type | Article | - |
dc.identifier.wosid | 000171292600016 | - |
dc.identifier.scopusid | 2-s2.0-0035753788 | - |
dc.type.rims | ART | - |
dc.citation.volume | 48 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 739 | - |
dc.citation.endingpage | 744 | - |
dc.citation.publicationname | ACTA BIOCHIMICA POLONICA | - |
dc.contributor.localauthor | Choe, Joonho | - |
dc.contributor.nonIdAuthor | Borowski, P | - |
dc.contributor.nonIdAuthor | Lang, M | - |
dc.contributor.nonIdAuthor | Niebuhr, A | - |
dc.contributor.nonIdAuthor | Haag, A | - |
dc.contributor.nonIdAuthor | Schmitz, H | - |
dc.contributor.nonIdAuthor | zur Wiesch, JS | - |
dc.contributor.nonIdAuthor | Siwecka, MA | - |
dc.contributor.nonIdAuthor | Kulikowski, T | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | HCV helicase | - |
dc.subject.keywordAuthor | enzyme inhibition | - |
dc.subject.keywordAuthor | ribavirin-5 &apos | - |
dc.subject.keywordAuthor | -triphosphate | - |
dc.subject.keywordPlus | HEPATITIS-C VIRUS | - |
dc.subject.keywordPlus | RNA HELICASE | - |
dc.subject.keywordPlus | NS3 PROTEIN | - |
dc.subject.keywordPlus | NUCLEOSIDE 5&apos | - |
dc.subject.keywordPlus | -TRIPHOSPHATES | - |
dc.subject.keywordPlus | BINDING ACTIVITY | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | NTPASE/HELICASE | - |
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