DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jee, C | ko |
dc.contributor.author | Lee, J | ko |
dc.contributor.author | Lee, JI | ko |
dc.contributor.author | Lee, WH | ko |
dc.contributor.author | Park, BJ | ko |
dc.contributor.author | Yu, JR | ko |
dc.contributor.author | Park, E | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.contributor.author | Ahnn, J | ko |
dc.date.accessioned | 2013-03-06T03:24:14Z | - |
dc.date.available | 2013-03-06T03:24:14Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004-03 | - |
dc.identifier.citation | FEBS LETTERS, v.561, pp.29 - 36 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://hdl.handle.net/10203/85677 | - |
dc.description.abstract | Protein localization in the postsynaptic density (PSD) of neurons is mediated by scaffolding proteins such as PSD-95 and Shank, which ensure proper function of receptors at the membrane. The Shank family of scaffolding proteins contain PDZ (PSD-95, Dig, and ZO-1) domains and have been implicated in the localizations of many receptor proteins including glutamate receptors in mammals. We have identified and characterized shn-1, the only homologue of Shank in Caenorhahditis elegans. The shn-1 gene shows approximately 40% identity over 1000 amino acids to rat Shanks. SHN-1 protein is localized in various tissues including neurons, pharynx and intestine. RNAi suppression of SHN-1 did not cause lethality or developmental abnormality. However, suppression of SHN-1 in the itr-1 (sa73) mutant, which has a defective inositol-1,4,5-trisphosphate (IP(3)) receptor, resulted in animals with altered defecation rhythm. Our data suggest a possible role of SHN-1 in affecting function of IP3 receptors in C. elegans. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject | POSTSYNAPTIC DENSITY PROTEINS | - |
dc.subject | CAENORHABDITIS-ELEGANS | - |
dc.subject | FILAMENTOUS ACTIN | - |
dc.subject | SYNAPTIC PROTEINS | - |
dc.subject | BINDING PROTEIN | - |
dc.subject | FAMILY | - |
dc.subject | CORTACTIN | - |
dc.subject | BRAIN | - |
dc.subject | HOMER | - |
dc.title | SHN-1, a Shank homologue in C-elegans, affects defecation rhythm via the inositol-1,4,5-trisphosphate receptor | - |
dc.type | Article | - |
dc.identifier.wosid | 000220244100005 | - |
dc.identifier.scopusid | 2-s2.0-1542268329 | - |
dc.type.rims | ART | - |
dc.citation.volume | 561 | - |
dc.citation.beginningpage | 29 | - |
dc.citation.endingpage | 36 | - |
dc.citation.publicationname | FEBS LETTERS | - |
dc.identifier.doi | 10.1016/S0014-5793(04)00107-3 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Jee, C | - |
dc.contributor.nonIdAuthor | Lee, J | - |
dc.contributor.nonIdAuthor | Lee, JI | - |
dc.contributor.nonIdAuthor | Lee, WH | - |
dc.contributor.nonIdAuthor | Park, BJ | - |
dc.contributor.nonIdAuthor | Yu, JR | - |
dc.contributor.nonIdAuthor | Park, E | - |
dc.contributor.nonIdAuthor | Ahnn, J | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | inositol-1,4,5-trisphosphate receptor | - |
dc.subject.keywordAuthor | postsynaptic density | - |
dc.subject.keywordAuthor | scaffolding protein | - |
dc.subject.keywordAuthor | receptor localization | - |
dc.subject.keywordAuthor | defecation cycle | - |
dc.subject.keywordPlus | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | POSTSYNAPTIC DENSITY PROTEINS | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | FILAMENTOUS ACTIN | - |
dc.subject.keywordPlus | SYNAPTIC PROTEINS | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | CORTACTIN | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | HOMER | - |
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